Niacinamide ： Acne
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'skincited.com';
const params = 'ingredient\u003Dniacinamide\u0026condition\u003Dacne';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
結論
A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.
Key Study Findings
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
vs: Placebo
効果: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
review
Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)
vs: Placebo
効果: None
None
Review
The adverse effects of oral niacin/nicotinamide - an overview of reviews.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Overview of reviews on niacin/nicotinamide adverse effects
Meta-Analysis
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Dose: Nicotinamide (vitamin B3)
vs: Placebo
Outcome: AK and NMSC incidence reduction
効果: None
None
対象集団: High-risk NMSC patients (RCTs)
Review
Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …
Dose: None
vs: Placebo
効果: None
None
Other
Nicotinamide: An Update and Review of Safety & Differences from Niacin.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Key Statistics
15
研究数
1200
参加者数
↑
Positive
A
グレード
Referenced Papers
Eye (London, England)
2025
1 件の引用
International journal of …
2025
International journal for …
2025
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Meta-Analysis
Nutrients
2023
16 件の引用
Journal of the …
2021
46 件の引用
Skin therapy letter
2020
13 件の引用
International journal of …
2005
22 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 14-16 mg/day NE (RDA)
- skinhealth:
- 500-1,500 mg/day oral nicotinamide
上限量： 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) | -- | Positive | -- |
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
推奨摂取タイミング： With meals; can be split into 2-3 doses
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated (no flushing unlike niacin)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)
既知の相互作用
- ● Anticonvulsants (carbamazepine — may increase niacinamide levels)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
- ● Isoniazid (competes for NAD+ pathways)
耐容上限摂取量： 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Niacinamide help with Acne?
Based on 15 studies with 1,200 participants, there is strong evidence from multiple clinical trials that Niacinamide may support Acne management. Our evidence grade is A (Strong Evidence).
How much Niacinamide should I take for Acne?
Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Niacinamide?
Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Niacinamide and Acne?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Acne
Niacinamide 他の症状・状態について
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
- [3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
- [4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。