Evidence-Based Supplement Reviews
Every skin claim cited.
We read the skin health studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Astaxanthin
antioxidantCarotenoid antioxidant that spans the full width of cell membranes, providing both internal and external free radical scavenging; 6,000x more …
Biotin
vitaminWater-soluble B-vitamin (B7) serving as a cofactor for carboxylase enzymes essential for fatty acid synthesis and amino acid metabolism; supports …
Collagen Peptides
collagen_proteinHydrolyzed collagen provides bioactive peptides (primarily Pro-Hyp and Hyp-Gly) that stimulate fibroblast proliferation and upregulate endogenous type I and type …
Glutathione
antioxidantTripeptide (glutamate-cysteine-glycine) serving as the body's master antioxidant; inhibits tyrosinase and shifts melanogenesis from eumelanin (dark) to pheomelanin (light); detoxifies …
Green Tea Extract
herbRich in catechin polyphenols, particularly epigallocatechin-3-gallate (EGCG); potent antioxidant that inhibits UV-induced MMP expression, reduces NF-kB activation, may protect against …
Hyaluronic Acid
collagen_proteinGlycosaminoglycan that retains up to 1,000x its weight in water, supporting dermal hydration; oral supplementation increases circulating hyaluronic acid fragments …
Top Conditions
Acne
Affects approximately 85% of people aged 12-24; 12-22% of adult women experience acne
Aging Skin & Wrinkles
Universal process; visible signs typically begin in late 20s to early 30s
Collagen Loss
Universal age-related process; accelerated in post-menopausal women
Dry Skin
Affects approximately 29-85% of adults depending on climate, age, and definition used
Eczema (Atopic Dermatitis)
Affects 15-20% of children and 1-3% of adults worldwide
Hair, Skin & Nails Health
One of the most popular supplement categories; hair/skin/nail supplement market exceeds $2 billion annually
Recent Evidence Updates
6 studies
8 studies
20 studies
5 studies
12 studies
Guides & Resources
Hydration and Skin Health: What the Science Actually Says
The relationship between water intake and skin hydration is one of the most widely discussed yet poorly understood topics in skin health. The popular belief …
lifestyleDiet for Healthy Skin: Evidence-Based Nutrition Strategies
The relationship between diet and skin health is supported by a growing body of epidemiological and clinical evidence. A 2020 systematic review in the Journal …
safetyBiotin Supplements and Lab Test Interference: A Hidden Risk
Biotin (vitamin B7, also known as vitamin H) is one of the most popular supplements for skin, hair, and nail health, available over the counter …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
No ads. No sponsored rankings. Just science.
Search PubMed
We search PubMed for every clinical study on supplement ingredients.
Extract Findings
We extract the key findings — sample sizes, study types, and results.
Grade A through F
We grade the evidence like a school report card — from A (strong) to F (negative).
Clear Answer
You get a clear answer in seconds — does this supplement actually work?
Cited Health Network
Explore evidence-based research across multiple health domains.
Evidence-based hair supplement reviews. Every claim backed by peer-reviewed rese
SleepCitedEvidence-based sleep supplement reviews. Every claim backed by peer-reviewed res
GutCitedEvidence-based gut health supplement reviews. Every claim about probiotics, preb
ImmuneCitedEvidence-based immune supplement reviews. Every claim about vitamin C, zinc, eld
BrainCitedEvidence-based brain and cognitive supplement reviews. Every claim about nootrop
WeightCitedEvidence-based weight management supplement reviews. Every claim about green tea
HeartCitedEvidence-based cardiovascular supplement reviews. Every claim about omega-3, CoQ
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.