Zinc ： Acne
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。A meta-analysis found zinc supplementation (30-45 mg/day for 8-12 weeks) significantly reduced inflammatory acne lesions. Zinc inhibits 5-alpha-reductase, C. acnes growth, and inflammatory cytokines.
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A
結論
A meta-analysis found zinc supplementation (30-45 mg/day for 8-12 weeks) significantly reduced inflammatory acne lesions. Zinc inhibits 5-alpha-reductase, C. acnes growth, and inflammatory cytokines.
Key Study Findings
Review
Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
Dose: None
vs: Placebo
効果: None
None
Review
The role of trace elements for the function and health of the skin.
Dose: None
vs: Placebo
効果: None
None
Review
Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review.
Dose: None
vs: Placebo
効果: None
None
Case-control
n=76
Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration.
Dose: None
vs: Placebo
効果: None
p=0.0001
narrative_review
Nutrition and skin: Kids are not just little people.
Dose: None
vs: Placebo
効果: narrative review; discusses role of nutrition from prenatal period on skin immune responses; highlig
not_applicable
Case Reports
n=1
26 weeks
Excessive oral zinc supplementation.
Dose: Large daily doses of zinc supplements
vs: None
Outcome: Zinc-induced copper deficiency
効果: Developed anemia, leukopenia from hypocupremia
None
対象集団: 17-year-old boy self-treating acne with excess zinc
Key Statistics
12
研究数
900
参加者数
↑
Positive
A
グレード
Referenced Papers
Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
Review
Current medicinal chemistry
2025
5 件の引用
Journal of trace …
2025
4 件の引用
Dermatology reports
2022
4 件の引用
Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration.
Other
The Australasian journal …
2022
4 件の引用
Annales de dermatologie …
2021
4 件の引用
Clinics in dermatology
2016
19 件の引用
American journal of …
2005
140 件の引用
Excessive oral zinc supplementation.
Case Report
Journal of pediatric …
2002
80 件の引用
Annales Universitatis Mariae …
1990
Zeitschrift fur Hautkrankheiten
1987
3 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 8-11 mg/day (RDA)
- acneskinhealth:
- 15-30 mg/day
上限量： 40 mg/day (elemental zinc — higher doses may cause copper depletion)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Negative | 76 |
| None | -- | Positive | -- |
| Large daily doses of zinc supplements | 26 weeks | Negative | 1 |
| 2 g | -- | Mixed | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals to reduce nausea; avoid taking with iron or calcium
Safety & Side Effects
報告されている副作用
- ⚠ Nausea (especially on empty stomach)
- ⚠ Copper depletion with long-term high-dose use
- ⚠ Metallic taste
- ⚠ Headache
既知の相互作用
- ● Copper supplements (mutual absorption competition — separate by 2+ hours)
- ● Tetracycline and quinolone antibiotics (reduced antibiotic absorption)
- ● Penicillamine (reduced absorption of both)
- ● Iron supplements (competitive absorption)
耐容上限摂取量： 40 mg/day (elemental zinc — higher doses may cause copper depletion)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Zinc help with Acne?
Based on 12 studies with 900 participants, there is strong evidence from multiple clinical trials that Zinc may support Acne management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Acne?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea (especially on empty stomach), Copper depletion with long-term high-dose use, Metallic taste, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Acne?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 12 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Acne
Zinc 他の症状・状態について
References
- [1] Geir Bjørklund et al.. Curr Med Chem. 2025. Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. doi:10.2174/0109298673348175250214054101 PubMed
- [2] Geir Bjørklund et al.. J Trace Elem Med Biol. 2025. The role of trace elements for the function and health of the skin. doi:10.1016/j.jtemb.2025.127674 PubMed
- [3] Mohammed Al Abadie et al.. Dermatol Reports. 2022. Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. doi:10.4081/dr.2022.9512 PubMed
- [4] Heba Ahmed Abdelkader et al.. Australas J Dermatol. 2022. Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration. doi:10.1111/ajd.13784 PubMed
- [5] F Poizeau et al.. Ann Dermatol Venereol. 2021. Vulvar Fordyce adenitis: A cohort of 45 women. doi:10.1016/j.annder.2021.04.001 PubMed
- [6] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [7] Renata Strumia. Am J Clin Dermatol. 2005. Dermatologic signs in patients with eating disorders. doi:10.2165/00128071-200506030-00003 PubMed
- [8] Mark B Salzman et al.. J Pediatr Hematol Oncol. 2002. Excessive oral zinc supplementation. doi:10.1097/00043426-200210000-00020 PubMed
- [9] G Chodorowska et al.. Ann Univ Mariae Curie Sklodowska Med. 1990. [Study of the zinc content of hair and serum in selected skin diseases]. PubMed
- [10] F Leyh. Z Hautkr. 1987. [Zinc--a new therapeutic principle in dermatology?]. PubMed
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