Niacinamide für Acne

A Evidenz Mehrere große klinische Studien zeigen übereinstimmend signifikante Vorteile.

A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.

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Fazit

Key Study Findings

laboratory/in vitro 26 weeks

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.

Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. vs.: Placebo Wirkung: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo None

review

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.

Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) vs.: Placebo Wirkung: None None

Review

The adverse effects of oral niacin/nicotinamide - an overview of reviews.

Dose: None vs.: None Outcome: None Wirkung: None None

Population: Overview of reviews on niacin/nicotinamide adverse effects

Meta-Analysis

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.

Dose: Nicotinamide (vitamin B3) vs.: Placebo Outcome: AK and NMSC incidence reduction Wirkung: None None

Population: High-risk NMSC patients (RCTs)

Review

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …

Dose: None vs.: Placebo Wirkung: None None

Other

Nicotinamide: An Update and Review of Safety & Differences from Niacin.

Dose: None vs.: None Outcome: None Wirkung: None None

Population: None

Key Statistics

Studien

1200

Teilnehmer

↑

Positive

Bewertung

Referenced Papers

The adverse effects of oral niacin/nicotinamide - an overview of reviews. Review

Eye (London, England) 2025 1 Zitierungen

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. Other

International journal of … 2025

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. Review

International journal for … 2025

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2023 16 Zitierungen

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. Review

Journal of the … 2021 46 Zitierungen

Nicotinamide: An Update and Review of Safety & Differences from Niacin. Other

Skin therapy letter 2020 13 Zitierungen

Final report of the safety assessment of niacinamide and niacin. Review

International journal of … 2005 22 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:: 14-16 mg/day NE (RDA)
skinhealth:: 500-1,500 mg/day oral nicotinamide

Obergrenze: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

In der Forschung untersuchte Dosierungen

Dosierung	Dauer	Wirkung	N
F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.	26 weeks	Positive	--
Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)	--	Positive	--
None	--	Mixed	--
Nicotinamide (vitamin B3)	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Niacinamide up to 5%; Niacin up to 0.1%	--	Mixed	--

Beste Einnahmezeit: With meals; can be split into 2-3 doses

Safety & Side Effects

Gemeldete Nebenwirkungen

⚠ Generally well-tolerated (no flushing unlike niacin)
⚠ Mild gastrointestinal discomfort at high doses
⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Bekannte Wechselwirkungen

● Anticonvulsants (carbamazepine — may increase niacinamide levels)
● Hepatotoxic drugs (potential additive liver effect at high doses)
● Isoniazid (competes for NAD+ pathways)

Tolerierbare Höchstaufnahmemenge: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Niacinamide help with Acne?

Based on 15 studies with 1,200 participants, there is strong evidence from multiple clinical trials that Niacinamide may support Acne management. Our evidence grade is A (Strong Evidence).

How much Niacinamide should I take for Acne?

Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Niacinamide?

Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Niacinamide and Acne?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

Andere Inhaltsstoffe für Acne

Zinc A Vitamin A (Retinol) C Omega-3 Fatty Acids C Turmeric (Curcumin) C Pantothenic Acid C Green Tea Extract D

Niacinamide für andere Beschwerden

UV Protection (Internal Photoprotection) A

Kurzfazit

Evidence Strength92%

High confidence

Studienübersicht

RCT (0)Meta (1)Other (14)

Alternativen vergleichen

Sehen Sie, wie andere Inhaltsstoffe bei dieser Beschwerde abschneiden.

Alle Inhaltsstoffe ansehen für Acne

Mehr erfahren

References

[1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
[2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
[3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
[4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
[5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
[6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
[7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed

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