Niacinamide 관련 여드름
A 근거 여러 대규모 임상 시험이 일관되게 유의미한 효과를 보여줍니다.A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.
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A
결론
A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.
Key Study Findings
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
vs: Placebo
효과: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
review
Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)
vs: Placebo
효과: None
None
Review
The adverse effects of oral niacin/nicotinamide - an overview of reviews.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Overview of reviews on niacin/nicotinamide adverse effects
Meta-Analysis
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Dose: Nicotinamide (vitamin B3)
vs: Placebo
Outcome: AK and NMSC incidence reduction
효과: None
None
대상 집단: High-risk NMSC patients (RCTs)
Review
Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …
Dose: None
vs: Placebo
효과: None
None
Other
Nicotinamide: An Update and Review of Safety & Differences from Niacin.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: None
Key Statistics
15
연구
1200
참여자
↑
Positive
A
등급
Referenced Papers
Eye (London, England)
2025
1 인용
International journal of …
2025
International journal for …
2025
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Meta-Analysis
Nutrients
2023
16 인용
Journal of the …
2021
46 인용
Skin therapy letter
2020
13 인용
International journal of …
2005
22 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 14-16 mg/day NE (RDA)
- skinhealth:
- 500-1,500 mg/day oral nicotinamide
상한량: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) | -- | Positive | -- |
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
권장 복용 시간: With meals; can be split into 2-3 doses
Safety & Side Effects
보고된 부작용
- ⚠ Generally well-tolerated (no flushing unlike niacin)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)
알려진 상호작용
- ● Anticonvulsants (carbamazepine — may increase niacinamide levels)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
- ● Isoniazid (competes for NAD+ pathways)
일일 최대 섭취 허용량: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Niacinamide help with 여드름?
Based on 15 studies with 1,200 participants, there is strong evidence from multiple clinical trials that Niacinamide may support 여드름 management. Our evidence grade is A (Strong Evidence).
How much Niacinamide should I take for 여드름?
Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Niacinamide?
Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Niacinamide and 여드름?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: 여드름
Niacinamide 다른 건강 상태에 대한 근거
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
- [3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
- [4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.