Niacinamide 用于 痤疮
A 证据 多项大型临床试验一致显示出显著的益处。A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.
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A
结论
A systematic review found topical niacinamide (4%) showed comparable efficacy to 1% clindamycin for acne. Oral nicotinamide supports sebum regulation and anti-inflammatory effects through NF-kB modulation.
Key Study Findings
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
vs: Placebo
效果: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
review
Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)
vs: Placebo
效果: None
None
Review
The adverse effects of oral niacin/nicotinamide - an overview of reviews.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Overview of reviews on niacin/nicotinamide adverse effects
Meta-Analysis
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Dose: Nicotinamide (vitamin B3)
vs: Placebo
Outcome: AK and NMSC incidence reduction
效果: None
None
研究人群: High-risk NMSC patients (RCTs)
Review
Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …
Dose: None
vs: Placebo
效果: None
None
Other
Nicotinamide: An Update and Review of Safety & Differences from Niacin.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Key Statistics
15
研究数量
1200
受试者
↑
Positive
A
等级
Referenced Papers
Eye (London, England)
2025
1 次引用
International journal of …
2025
International journal for …
2025
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Meta-Analysis
Nutrients
2023
16 次引用
Journal of the …
2021
46 次引用
Skin therapy letter
2020
13 次引用
International journal of …
2005
22 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 14-16 mg/day NE (RDA)
- skinhealth:
- 500-1,500 mg/day oral nicotinamide
上限： 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) | -- | Positive | -- |
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
最佳服用时间： With meals; can be split into 2-3 doses
Safety & Side Effects
已报告的副作用
- ⚠ Generally well-tolerated (no flushing unlike niacin)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)
已知相互作用
- ● Anticonvulsants (carbamazepine — may increase niacinamide levels)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
- ● Isoniazid (competes for NAD+ pathways)
可耐受最高摄入量： 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Niacinamide help with 痤疮?
Based on 15 studies with 1,200 participants, there is strong evidence from multiple clinical trials that Niacinamide may support 痤疮 management. Our evidence grade is A (Strong Evidence).
How much Niacinamide should I take for 痤疮?
Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Niacinamide?
Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Niacinamide and 痤疮?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 痤疮
Niacinamide 用于其他健康状况
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
- [3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
- [4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
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