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Pantothenic Acid ： Acne

C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

An RCT found high-dose pantothenic acid (2,200 mg/day) reduced total facial acne lesions by 68.2% after 12 weeks. Mechanism involves CoA-mediated fatty acid oxidation in sebaceous glands.

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            C

        

        

            
結論

            
            
An RCT found high-dose pantothenic acid (2,200 mg/day) reduced total facial acne lesions by 68.2% after 12 weeks. Mechanism involves CoA-mediated fatty acid oxidation in sebaceous glands.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    review
                
                
                
                
            

            
                Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
            
            

                
                Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)
                
                
                vs: Placebo
                
                
                
                効果: None
                
                
                None
                
            

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
研究数

    

    

        
200

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal for …
                        2025
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
5 mg/day (AI)

                    

                    
                    

                        
acneskinhealth:

                        
500-2,000 mg/day (high-dose protocol)

                    

                    
                

                
                

                    上限量： Not established; high doses (10,000+ mg/day) may cause GI distress
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals; split doses recommended for high amounts
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Diarrhea at very high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            No significant drug interactions documented at typical doses
                        
    • 
                        
                        
  • 
                            ●
                            May enhance acetylcholine production (theoretical interaction with cholinergic drugs)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Not established; high doses (10,000+ mg/day) may cause GI distress
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Pantothenic Acid help with Acne?
            
        
        

            Based on 3 studies with 200 participants, there is limited but promising evidence that Pantothenic Acid may support Acne management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Pantothenic Acid should I take for Acne?
            
        
        

            Studies have used various dosages. A commonly studied range is 5 mg/day (AI). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Pantothenic Acid?
            
        
        

            Reported side effects may include Diarrhea at very high doses, Mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Pantothenic Acid and Acne?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Feiya Du et al..
      Int J Vitam Nutr Res.
      2025.
      Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
      doi:10.31083/IJVNR39087
      PubMed
    
    2. 
    
  















    

        FDAに関する免責事項:
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