Niacinamide 用于 紫外线防护（内源性光防护）
A 证据 多项大型临床试验一致显示出显著的益处。The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.
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A
结论
The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.
Key Study Findings
laboratory/in vitro
26 weeks
Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.
Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.
vs: Placebo
效果: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo
None
review
Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.
Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)
vs: Placebo
效果: None
None
Review
The adverse effects of oral niacin/nicotinamide - an overview of reviews.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Overview of reviews on niacin/nicotinamide adverse effects
Meta-Analysis
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Dose: Nicotinamide (vitamin B3)
vs: Placebo
Outcome: AK and NMSC incidence reduction
效果: None
None
研究人群: High-risk NMSC patients (RCTs)
Review
Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …
Dose: None
vs: Placebo
效果: None
None
Other
Nicotinamide: An Update and Review of Safety & Differences from Niacin.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Key Statistics
5
研究数量
686
受试者
↑
Positive
A
等级
Referenced Papers
Eye (London, England)
2025
1 次引用
International journal of …
2025
International journal for …
2025
The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
Meta-Analysis
Nutrients
2023
16 次引用
Journal of the …
2021
46 次引用
Skin therapy letter
2020
13 次引用
International journal of …
2005
22 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 14-16 mg/day NE (RDA)
- skinhealth:
- 500-1,500 mg/day oral nicotinamide
上限： 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) | -- | Positive | -- |
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
最佳服用时间： With meals; can be split into 2-3 doses
Safety & Side Effects
已报告的副作用
- ⚠ Generally well-tolerated (no flushing unlike niacin)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)
已知相互作用
- ● Anticonvulsants (carbamazepine — may increase niacinamide levels)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
- ● Isoniazid (competes for NAD+ pathways)
可耐受最高摄入量： 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Niacinamide help with 紫外线防护（内源性光防护）?
Based on 5 studies with 686 participants, there is strong evidence from multiple clinical trials that Niacinamide may support 紫外线防护（内源性光防护） management. Our evidence grade is A (Strong Evidence).
How much Niacinamide should I take for 紫外线防护（内源性光防护）?
Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Niacinamide?
Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Niacinamide and 紫外线防护（内源性光防护）?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 5 peer-reviewed studies with 686 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 紫外线防护（内源性光防护）
Niacinamide 用于其他健康状况
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
- [3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
- [4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
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