Saw Palmetto 用于 痤疮
D 研究 目前仅存在初步研究（实验室研究、病例报告）。Preliminary research suggests saw palmetto's anti-androgenic effects (5-alpha-reductase inhibition) may reduce sebum production. Limited skin-specific evidence.
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D
结论
Preliminary research suggests saw palmetto's anti-androgenic effects (5-alpha-reductase inhibition) may reduce sebum production. Limited skin-specific evidence.
Key Study Findings
in vitro/ex vivo study
A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond …
Dose: USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu
vs: Placebo
效果: USPlus DERM IC50=0.39 μg/mL (vs 29.1 μg/mL standard extract); 0.4 μg/mL significantly reduced melani
None
case report
n=1
Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia.
Dose: minoxidil 4% with retinoic acid in propylene glycol base; saw palmetto (Serenoa repens) topical extr
vs: Placebo
效果: None
None
Key Statistics
2
研究数量
100
受试者
↑
Positive
D
等级
Referenced Papers
International journal of …
2025
1 次引用
Expert opinion on …
2020
147 次引用
Journal of cosmetic …
2019
100 次引用
The Australasian journal …
2002
20 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 320 mg/day standardized extract
- skinacne:
- 320 mg/day
上限： Not established; generally well-tolerated
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| USPlus DERM (lipidosterolic extract of Serenoa repens) at 0.4 and 10 μg/mL in hair follicle organ cu | -- | Positive | -- |
| minoxidil 4% with retinoic acid in propylene glycol base; saw palmetto (Serenoa repens) topical extr | -- | Negative | 1 |
最佳服用时间： With meals to reduce gastrointestinal side effects
Safety & Side Effects
已报告的副作用
- ⚠ Mild gastrointestinal discomfort
- ⚠ Headache (rare)
- ⚠ Dizziness (rare)
已知相互作用
- ● Anticoagulants (may have mild antiplatelet effects)
- ● Hormonal medications (oral contraceptives, HRT — may interfere)
- ● Finasteride and dutasteride (additive 5-alpha-reductase inhibition)
可耐受最高摄入量： Not established; generally well-tolerated
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Saw Palmetto help with 痤疮?
Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Saw Palmetto may support 痤疮 management. Our evidence grade is D (Very Early Research).
How much Saw Palmetto should I take for 痤疮?
Studies have used various dosages. A commonly studied range is 320 mg/day standardized extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Saw Palmetto?
Reported side effects may include Mild gastrointestinal discomfort, Headache (rare), Dizziness (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Saw Palmetto and 痤疮?
We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
References
- [1] David Broadley et al.. Int J Cosmet Sci. 2025. A proprietary lipidosterolic extract of Serenoa repens promotes hair growth through mechanisms that extend beyond 5-alpha reductase inhibition: Insights from … doi:10.1111/ics.70035 PubMed
- [2] Katherine York et al.. Expert Opin Pharmacother. 2020. A review of the treatment of male pattern hair loss. doi:10.1080/14656566.2020.1721463 PubMed
- [3] Maria Yusuf Dhariwala et al.. J Cosmet Dermatol. 2019. An overview of herbal alternatives in androgenetic alopecia. doi:10.1111/jocd.12930 PubMed
- [4] Rodney D Sinclair et al.. Australas J Dermatol. 2002. Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia. doi:10.1046/j.1440-0960.2002.00620.x PubMed
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