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Zinc para Acne

A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.

A meta-analysis found zinc supplementation (30-45 mg/day for 8-12 weeks) significantly reduced inflammatory acne lesions. Zinc inhibits 5-alpha-reductase, C. acnes growth, and inflammatory cytokines.

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Conclusão

            
            
A meta-analysis found zinc supplementation (30-45 mg/day for 8-12 weeks) significantly reduced inflammatory acne lesions. Zinc inhibits 5-alpha-reductase, C. acnes growth, and inflammatory cytokines.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efeito: None
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                The role of trace elements for the function and health of the skin.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efeito: None
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efeito: None
                
                
                None
                
            

            
        

        
        

            

                
                    Case-control
                
                
                n=76
                
                
                
            

            
                Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efeito: None
                
                
                p=0.0001
                
            

            
        

        
        

            

                
                    narrative_review
                
                
                
                
            

            
                Nutrition and skin: Kids are not just little people.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efeito: narrative review; discusses role of nutrition from prenatal period on skin immune responses; highlig
                
                
                not_applicable
                
            

            
        

        
        

            

                
                    Case Reports
                
                
                n=1
                
                
                26 weeks
                
                
            

            
                Excessive oral zinc supplementation.
            
            

                
                Dose: Large daily doses of zinc supplements
                
                
                vs: None
                
                
                Outcome: Zinc-induced copper deficiency
                
                
                Efeito: Developed anemia, leukopenia from hypocupremia
                
                
                None
                
            

            
            
População: 17-year-old boy self-treating acne with excess zinc

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
12

        
Estudos

    

    

        
900

        
Participantes

    

    

        
            
            ↑
            
        
        
Positive

    

    

        A

        
Nota

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Current medicinal chemistry
                        2025
                        
                        5 citações
                        
                    

                

                
                

                    

                        
                            The role of trace elements for the function and health of the skin.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of trace …
                        2025
                        
                        4 citações
                        
                    

                

                
                

                    

                        
                            Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Dermatology reports
                        2022
                        
                        4 citações
                        
                    

                

                
                

                    

                        
                            Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        The Australasian journal …
                        2022
                        
                        4 citações
                        
                    

                

                
                

                    

                        
                            Vulvar Fordyce adenitis: A cohort of 45 women.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Annales de dermatologie …
                        2021
                        
                        4 citações
                        
                    

                

                
                

                    

                        
                            Nutrition and skin: Kids are not just little people.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Clinics in dermatology
                        2016
                        
                        19 citações
                        
                    

                

                
                

                    

                        
                            Dermatologic signs in patients with eating disorders.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        American journal of …
                        2005
                        
                        140 citações
                        
                    

                

                
                

                    

                        
                            Excessive oral zinc supplementation.
                        
                        
                            
                                Case Report
                            
                            
                            
                        
                    

                    

                        Journal of pediatric …
                        2002
                        
                        80 citações
                        
                    

                

                
                

                    

                        
                            [Study of the zinc content of hair and serum in selected skin diseases].
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Annales Universitatis Mariae …
                        1990
                        
                    

                

                
                

                    

                        
                            [Zinc--a new therapeutic principle in dermatology?].
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Zeitschrift fur Hautkrankheiten
                        1987
                        
                        3 citações
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosagens Comumente Utilizadas

                

                    
                    

                        
general:

                        
8-11 mg/day (RDA)

                    

                    
                    

                        
acneskinhealth:

                        
15-30 mg/day

                    

                    
                

                
                

                    Limite superior: 40 mg/day (elemental zinc — higher doses may cause copper depletion)
                

                
            

            

            
            

                
Dosagens Estudadas em Pesquisas

                

                    

                        
                            

                                Dosagem
                                Duração
                                Efeito
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Negative
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Negative
                                    
                                
                                76
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                Large daily doses of zinc supplements
                                26 weeks
                                
                                    
                                    Negative
                                    
                                
                                1
                            

                            
                            

                                2 g
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Melhor horário: With meals to reduce nausea; avoid taking with iron or calcium
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efeitos Colaterais Relatados

                    
    
                        
                        
  • 
                            ⚠
                            Nausea (especially on empty stomach)
                        
    • 
                        
                        
  • 
                            ⚠
                            Copper depletion with long-term high-dose use
                        
    • 
                        
                        
  • 
                            ⚠
                            Metallic taste
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                    

                

                

                
                

                    
Interações Conhecidas

                    
    
                        
                        
  • 
                            ●
                            Copper supplements (mutual absorption competition — separate by 2+ hours)
                        
    • 
                        
                        
  • 
                            ●
                            Tetracycline and quinolone antibiotics (reduced antibiotic absorption)
                        
    • 
                        
                        
  • 
                            ●
                            Penicillamine (reduced absorption of both)
                        
    • 
                        
                        
  • 
                            ●
                            Iron supplements (competitive absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Ingestão máxima tolerável: 40 mg/day (elemental zinc — higher doses may cause copper depletion)
                    

                

                
            

            

                Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Zinc help with Acne?
            
        
        

            Based on 12 studies with 900 participants, there is strong evidence from multiple clinical trials that Zinc may support Acne management. Our evidence grade is A (Strong Evidence).
        

    

    
    

        
            How much Zinc should I take for Acne?
            
        
        

            Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Zinc?
            
        
        

            Reported side effects may include Nausea (especially on empty stomach), Copper depletion with long-term high-dose use, Metallic taste, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Zinc and Acne?
            
        
        

            We rate the evidence as Grade A (Strong Evidence). This rating is based on 12 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Zinc para outras condições

                    

                        
                        
                            Wound Healing
                            A

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Geir Bjørklund et al..
      Curr Med Chem.
      2025.
      Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
      doi:10.2174/0109298673348175250214054101
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Geir Bjørklund et al..
      J Trace Elem Med Biol.
      2025.
      The role of trace elements for the function and health of the skin.
      doi:10.1016/j.jtemb.2025.127674
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Mohammed Al Abadie et al..
      Dermatol Reports.
      2022.
      Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review.
      doi:10.4081/dr.2022.9512
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Heba Ahmed Abdelkader et al..
      Australas J Dermatol.
      2022.
      Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration.
      doi:10.1111/ajd.13784
      PubMed
    
    5. 
    
    
  5. 
      [5]
      F Poizeau et al..
      Ann Dermatol Venereol.
      2021.
      Vulvar Fordyce adenitis: A cohort of 45 women.
      doi:10.1016/j.annder.2021.04.001
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Meagen McCusker et al..
      Clin Dermatol.
      2016.
      Nutrition and skin: Kids are not just little people.
      doi:10.1016/j.clindermatol.2016.07.004
      PubMed
    
    7. 
    
    
  7. 
      [7]
      Renata Strumia.
      Am J Clin Dermatol.
      2005.
      Dermatologic signs in patients with eating disorders.
      doi:10.2165/00128071-200506030-00003
      PubMed
    
    8. 
    
    
  8. 
      [8]
      Mark B Salzman et al..
      J Pediatr Hematol Oncol.
      2002.
      Excessive oral zinc supplementation.
      doi:10.1097/00043426-200210000-00020
      PubMed
    
    9. 
    
    
  9. 
      [9]
      G Chodorowska et al..
      Ann Univ Mariae Curie Sklodowska Med.
      1990.
      [Study of the zinc content of hair and serum in selected skin diseases].
      
      PubMed
    
    10. 
    
    
  10. 
      [10]
      F Leyh.
      Z Hautkr.
      1987.
      [Zinc--a new therapeutic principle in dermatology?].
      
      PubMed
    
    11. 
    
  















    

        Aviso Legal da FDA:
        Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.