Zinc ： Wound Healing
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。Well-established evidence that zinc is essential for wound healing. Zinc deficiency impairs all phases of repair. Supplementation in deficient individuals may help accelerate wound closure.
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A
結論
Well-established evidence that zinc is essential for wound healing. Zinc deficiency impairs all phases of repair. Supplementation in deficient individuals may help accelerate wound closure.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Elite/professional cyclists nutrition review
Observational Study
Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Dogs with intervertebral disc herniation
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
効果: None
None
対象集団: Diabetic wound model
Systematic Review
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Dose: None
vs: Control
Outcome: Wound healing
効果: None
None
対象集団: Diabetic patients
In Vitro
Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing.
Dose: SA-Arg-Zn2+ hydrogel
vs: Other dressing materials
Outcome: Wound healing, antibacterial, antioxidant
効果: None
None
対象集団: In vitro + animal wound model
Other
[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: chronic wounds and have been linked to delayed wound healing and dehiscence
Key Statistics
18
研究数
1500
参加者数
↑
Positive
A
グレード
Referenced Papers
Journal of colloid …
2025
8 件の引用
International journal of …
2025
2 件の引用
Metabolites
2025
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
Nutrition (Burbank, Los …
2024
12 件の引用
Carbohydrate polymers
2023
86 件の引用
Theranostics
2023
65 件の引用
Heliyon
2022
117 件の引用
Nutricion hospitalaria
2021
20 件の引用
The Cochrane database …
2020
33 件の引用
International journal of …
2019
265 件の引用
Annals of internal …
2015
110 件の引用
Inflammatory bowel diseases
2012
224 件の引用
Current opinion in …
2009
66 件の引用
American journal of …
2005
140 件の引用
Metal ions in …
2004
Zinc supplementation.
Other
Journal of the …
2000
52 件の引用
Nutrition and wound healing.
Review
JPEN. Journal of …
1994
72 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 8-11 mg/day (RDA)
- acneskinhealth:
- 15-30 mg/day
上限量： 40 mg/day (elemental zinc — higher doses may cause copper depletion)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| SA-Arg-Zn2+ hydrogel | -- | Positive | -- |
| None | -- | Positive | -- |
| 20 g | -- | Neutral | 629 |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals to reduce nausea; avoid taking with iron or calcium
Safety & Side Effects
報告されている副作用
- ⚠ Nausea (especially on empty stomach)
- ⚠ Copper depletion with long-term high-dose use
- ⚠ Metallic taste
- ⚠ Headache
既知の相互作用
- ● Copper supplements (mutual absorption competition — separate by 2+ hours)
- ● Tetracycline and quinolone antibiotics (reduced antibiotic absorption)
- ● Penicillamine (reduced absorption of both)
- ● Iron supplements (competitive absorption)
耐容上限摂取量： 40 mg/day (elemental zinc — higher doses may cause copper depletion)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Zinc help with Wound Healing?
Based on 18 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Wound Healing management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Wound Healing?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea (especially on empty stomach), Copper depletion with long-term high-dose use, Metallic taste, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Wound Healing?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 18 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Wound Healing
Zinc 他の症状・状態について
References
- [1] Jialiang Pan et al.. J Colloid Interface Sci. 2025. Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. doi:10.1016/j.jcis.2025.138423 PubMed
- [2] Patrick B Wilson et al.. Int J Sport Nutr Exerc Metab. 2025. UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. doi:10.1123/ijsnem.2025-0144 PubMed
- [3] Anita Horvatić et al.. Metabolites. 2025. Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. doi:10.3390/metabo15060396 PubMed
- [4] Allan Carlos Soares do Espírito Santo et al.. Nutrition. 2024. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. doi:10.1016/j.nut.2024.112449 PubMed
- [5] Ganzhe Mao et al.. Carbohydr Polym. 2023. Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. doi:10.1016/j.carbpol.2023.120757 PubMed
- [6] Yating Yang et al.. Theranostics. 2023. Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. doi:10.7150/thno.84118 PubMed
- [7] Ajay Kumar et al.. Heliyon. 2022. A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.). doi:10.1016/j.heliyon.2021.e08669 PubMed
- [8] Rosa María Martínez García et al.. Nutr Hosp. 2021. [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. doi:10.20960/nh.03800 PubMed
- [9] Zena Eh Moore et al.. Cochrane Database Syst Rev. 2020. Nutritional interventions for treating foot ulcers in people with diabetes. doi:10.1002/14651858.CD011378.pub2 PubMed
- [10] Martina Barchitta et al.. Int J Mol Sci. 2019. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. doi:10.3390/ijms20051119 PubMed
- [11] Emanuele Cereda et al.. Ann Intern Med. 2015. A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. doi:10.7326/M14-0696 PubMed
- [12] Caroline Hwang et al.. Inflamm Bowel Dis. 2012. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. doi:10.1002/ibd.22906 PubMed
- [13] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
- [14] Renata Strumia. Am J Clin Dermatol. 2005. Dermatologic signs in patients with eating disorders. doi:10.2165/00128071-200506030-00003 PubMed
- [15] Paul W Jones et al.. Met Ions Biol Syst. 2004. The use and role of zinc and its compounds in wound healing. PubMed
- [16] C J Klein. J Am Diet Assoc. 2000. Zinc supplementation. doi:10.1016/S0002-8223(00)00331-X PubMed
- [17] J E Albina. JPEN J Parenter Enteral Nutr. 1994. Nutrition and wound healing. doi:10.1177/014860719401800417 PubMed
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