Resveratrol 用于 皮肤老化与皱纹
C 证据 来自小型研究的证据有限，但存在一些积极信号。In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.
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C
结论
In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.
Key Study Findings
Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of TCM compounds in autoimmune skin diseases
Animal study
Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.
Dose: PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified
vs: Placebo
效果: None
None
Review
Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review.
Dose: None
vs: None
Outcome: Inflammatory markers
效果: None
None
研究人群: None
Review
Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases.
Dose: None
vs: None
Outcome: Antioxidant and neuroprotective effects
效果: None
None
研究人群: Cerebrovascular disease populations
Review
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Status epilepticus and temporal lobe epilepsy
Randomized Controlled Trial
n=36
Double-blind
Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus.
Dose: 75 mg trans-resveratrol (acute single dose)
vs: placebo
Outcome: neurovascular coupling capacity (CVR)
效果: improved CVR after acute resveratrol
<0.05
研究人群: Adults with type 2 diabetes mellitus
Key Statistics
4
研究数量
200
受试者
↑
Positive
C
等级
Referenced Papers
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 次引用
Pharmaceuticals (Basel, Switzerland)
2024
14 次引用
International journal of …
2024
3 次引用
Frontiers in pharmacology
2022
37 次引用
Frontiers in neurology
2017
48 次引用
Nutrients
2016
83 次引用
Journal of cardiovascular …
2009
297 次引用
The Journal of …
2009
220 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 150-500 mg/day
- skinhealth:
- 250-500 mg/day trans-resveratrol
上限： Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| 75 mg trans-resveratrol (acute single dose) | -- | Positive | 36 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
最佳服用时间： With meals for improved absorption; low oral bioavailability (~1-2%)
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort at high doses
- ⚠ Diarrhea
- ⚠ May affect platelet aggregation
已知相互作用
- ● Anticoagulants (may have antiplatelet effects)
- ● CYP450 substrates (may inhibit drug metabolism)
- ● Estrogen-sensitive conditions (has weak estrogenic activity)
可耐受最高摄入量： Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Resveratrol help with 皮肤老化与皱纹?
Based on 4 studies with 200 participants, there is limited but promising evidence that Resveratrol may support 皮肤老化与皱纹 management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for 皮肤老化与皱纹?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort at high doses, Diarrhea, May affect platelet aggregation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and 皮肤老化与皱纹?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
References
- [1] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
- [2] Mohd Farhan et al.. Pharmaceuticals (Basel). 2024. Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review. doi:10.3390/ph17060670 PubMed
- [3] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
- [4] Qing Wang et al.. Front Pharmacol. 2022. Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. doi:10.3389/fphar.2022.948889 PubMed
- [5] Olagide W Castro et al.. Front Neurol. 2017. Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? doi:10.3389/fneur.2017.00603 PubMed
- [6] Rachel H X Wong et al.. Nutrients. 2016. Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. doi:10.3390/nu8070425 PubMed
- [7] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
- [8] Timothy Mainardi et al.. J Allergy Clin Immunol. 2009. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. doi:10.1016/j.jaci.2008.12.023 PubMed
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