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Resveratrol для Aging Skin & Wrinkles

C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.

In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.

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C

Итог

In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.

Key Study Findings

Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None или: None Outcome: None Эффект: None None

Популяция: Review of TCM compounds in autoimmune skin diseases

Animal study
Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.
Dose: PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified или: Placebo Эффект: None None
Review
Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review.
Dose: None или: None Outcome: Inflammatory markers Эффект: None None

Популяция: None

Review
Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases.
Dose: None или: None Outcome: Antioxidant and neuroprotective effects Эффект: None None

Популяция: Cerebrovascular disease populations

Review
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are …
Dose: None или: None Outcome: None Эффект: None None

Популяция: Status epilepticus and temporal lobe epilepsy

Randomized Controlled Trial n=36 Double-blind
Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus.
Dose: 75 mg trans-resveratrol (acute single dose) или: placebo Outcome: neurovascular coupling capacity (CVR) Эффект: improved CVR after acute resveratrol <0.05

Популяция: Adults with type 2 diabetes mellitus

Key Statistics

4

Исследования

200

Участники

Positive

C

Оценка

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
150-500 mg/day
skinhealth:
250-500 mg/day trans-resveratrol

Верхний предел: Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Mixed --
PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified -- Positive --
None -- Neutral --
None -- Positive --
None -- Mixed --
75 mg trans-resveratrol (acute single dose) -- Positive 36
None -- Mixed --
None -- Positive --

Лучшее время приёма: With meals for improved absorption; low oral bioavailability (~1-2%)

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Gastrointestinal discomfort at high doses
  • Diarrhea
  • May affect platelet aggregation

Известные взаимодействия

  • Anticoagulants (may have antiplatelet effects)
  • CYP450 substrates (may inhibit drug metabolism)
  • Estrogen-sensitive conditions (has weak estrogenic activity)

Допустимый верхний уровень потребления: Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Resveratrol help with Aging Skin & Wrinkles?
Based on 4 studies with 200 participants, there is limited but promising evidence that Resveratrol may support Aging Skin & Wrinkles management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Aging Skin & Wrinkles?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort at high doses, Diarrhea, May affect platelet aggregation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Aging Skin & Wrinkles?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

References

  1. [1] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
  2. [2] Mohd Farhan et al.. Pharmaceuticals (Basel). 2024. Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review. doi:10.3390/ph17060670 PubMed
  3. [3] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
  4. [4] Qing Wang et al.. Front Pharmacol. 2022. Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. doi:10.3389/fphar.2022.948889 PubMed
  5. [5] Olagide W Castro et al.. Front Neurol. 2017. Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? doi:10.3389/fneur.2017.00603 PubMed
  6. [6] Rachel H X Wong et al.. Nutrients. 2016. Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. doi:10.3390/nu8070425 PubMed
  7. [7] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
  8. [8] Timothy Mainardi et al.. J Allergy Clin Immunol. 2009. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. doi:10.1016/j.jaci.2008.12.023 PubMed

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.