Resveratrol untuk Aging Skin & Wrinkles

Q: Does Resveratrol help with Aging Skin & Wrinkles?

Based on 4 studies with 200 participants, there is limited but promising evidence that Resveratrol may support Aging Skin & Wrinkles management. Our evidence grade is C (Some Evidence).

Q: How much Resveratrol should I take for Aging Skin & Wrinkles?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort at high doses, Diarrhea, May affect platelet aggregation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Resveratrol and Aging Skin & Wrinkles?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.

In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.

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Kesimpulan

In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.

Key Study Findings

Systematic Review

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Review of TCM compounds in autoimmune skin diseases

Animal study

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.

Dose: PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified vs: Placebo Efek: None None

Review

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review.

Dose: None vs: None Outcome: Inflammatory markers Efek: None None

Populasi: None

Review

Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases.

Dose: None vs: None Outcome: Antioxidant and neuroprotective effects Efek: None None

Populasi: Cerebrovascular disease populations

Review

Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are …

Dose: None vs: None Outcome: None Efek: None None

Populasi: Status epilepticus and temporal lobe epilepsy

Randomized Controlled Trial n=36 Double-blind

Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus.

Dose: 75 mg trans-resveratrol (acute single dose) vs: placebo Outcome: neurovascular coupling capacity (CVR) Efek: improved CVR after acute resveratrol <0.05

Populasi: Adults with type 2 diabetes mellitus

Key Statistics

Studi

200

Peserta

↑

Positive

Peringkat

Referenced Papers

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. Systematic Review

Frontiers in immunology 2025 1 sitasi

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review. Review

Pharmaceuticals (Basel, Switzerland) 2024 14 sitasi

Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. Other

International journal of … 2024 3 sitasi

Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. Review

Frontiers in pharmacology 2022 37 sitasi

Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? Review

Frontiers in neurology 2017 48 sitasi

Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. RCT

Nutrients 2016 83 sitasi

Grapes, wines, resveratrol, and heart health. Review

Journal of cardiovascular … 2009 297 sitasi

Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. Review

The Journal of … 2009 220 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 150-500 mg/day
skinhealth:: 250-500 mg/day trans-resveratrol

Batas atas: Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified	--	Positive	--
None	--	Neutral	--
None	--	Positive	--
None	--	Mixed	--
75 mg trans-resveratrol (acute single dose)	--	Positive	36
None	--	Mixed	--
None	--	Positive	--

Waktu terbaik diminum: With meals for improved absorption; low oral bioavailability (~1-2%)

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Gastrointestinal discomfort at high doses
⚠ Diarrhea
⚠ May affect platelet aggregation

Interaksi yang Diketahui

● Anticoagulants (may have antiplatelet effects)
● CYP450 substrates (may inhibit drug metabolism)
● Estrogen-sensitive conditions (has weak estrogenic activity)

Asupan atas yang dapat ditoleransi: Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Resveratrol help with Aging Skin & Wrinkles?

Based on 4 studies with 200 participants, there is limited but promising evidence that Resveratrol may support Aging Skin & Wrinkles management. Our evidence grade is C (Some Evidence).

How much Resveratrol should I take for Aging Skin & Wrinkles?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort at high doses, Diarrhea, May affect platelet aggregation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Resveratrol and Aging Skin & Wrinkles?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Bahan lain untuk Aging Skin & Wrinkles

Collagen Peptides A Vitamin C B Astaxanthin B Hyaluronic Acid B Pine Bark Extract (Pycnogenol) B Vitamin E C

Kesimpulan Singkat

In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (1)Meta (0)Other (3)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Aging Skin & Wrinkles

Pelajari Lebih Lanjut

References

[1] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
[2] Mohd Farhan et al.. Pharmaceuticals (Basel). 2024. Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review. doi:10.3390/ph17060670 PubMed
[3] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
[4] Qing Wang et al.. Front Pharmacol. 2022. Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. doi:10.3389/fphar.2022.948889 PubMed
[5] Olagide W Castro et al.. Front Neurol. 2017. Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? doi:10.3389/fneur.2017.00603 PubMed
[6] Rachel H X Wong et al.. Nutrients. 2016. Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. doi:10.3390/nu8070425 PubMed
[7] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
[8] Timothy Mainardi et al.. J Allergy Clin Immunol. 2009. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. doi:10.1016/j.jaci.2008.12.023 PubMed

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Resveratrol untuk Aging Skin & Wrinkles

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Kesimpulan

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosis yang Umum Digunakan

Dosis yang Diteliti dalam Penelitian

Safety & Side Effects

Efek Samping yang Dilaporkan

Interaksi yang Diketahui

Frequently Asked Questions

Related Evidence

Bahan lain untuk Aging Skin & Wrinkles

References