Resveratrol ： Aging Skin & Wrinkles
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.
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C
結論
In vitro evidence is strong for anti-aging effects (SIRT1 activation, MMP inhibition). Oral bioavailability is extremely low (<2%), limiting clinical evidence for oral supplementation.
Key Study Findings
Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of TCM compounds in autoimmune skin diseases
Animal study
Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies.
Dose: PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified
vs: Placebo
効果: None
None
Review
Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review.
Dose: None
vs: None
Outcome: Inflammatory markers
効果: None
None
対象集団: None
Review
Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases.
Dose: None
vs: None
Outcome: Antioxidant and neuroprotective effects
効果: None
None
対象集団: Cerebrovascular disease populations
Review
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Status epilepticus and temporal lobe epilepsy
Randomized Controlled Trial
n=36
Double-blind
Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus.
Dose: 75 mg trans-resveratrol (acute single dose)
vs: placebo
Outcome: neurovascular coupling capacity (CVR)
効果: improved CVR after acute resveratrol
<0.05
対象集団: Adults with type 2 diabetes mellitus
Key Statistics
4
研究数
200
参加者数
↑
Positive
C
グレード
Referenced Papers
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Systematic Review
Frontiers in immunology
2025
1 件の引用
Pharmaceuticals (Basel, Switzerland)
2024
14 件の引用
International journal of …
2024
3 件の引用
Frontiers in pharmacology
2022
37 件の引用
Frontiers in neurology
2017
48 件の引用
Nutrients
2016
83 件の引用
Journal of cardiovascular …
2009
297 件の引用
The Journal of …
2009
220 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 150-500 mg/day
- skinhealth:
- 250-500 mg/day trans-resveratrol
上限量： Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| PPD-Lip@RES (resveratrol-loaded nanovesicle), dose not specified | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| 75 mg trans-resveratrol (acute single dose) | -- | Positive | 36 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals for improved absorption; low oral bioavailability (~1-2%)
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort at high doses
- ⚠ Diarrhea
- ⚠ May affect platelet aggregation
既知の相互作用
- ● Anticoagulants (may have antiplatelet effects)
- ● CYP450 substrates (may inhibit drug metabolism)
- ● Estrogen-sensitive conditions (has weak estrogenic activity)
耐容上限摂取量： Generally well-tolerated up to 1,500 mg/day; GI discomfort above 2,500 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Resveratrol help with Aging Skin & Wrinkles?
Based on 4 studies with 200 participants, there is limited but promising evidence that Resveratrol may support Aging Skin & Wrinkles management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Aging Skin & Wrinkles?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort at high doses, Diarrhea, May affect platelet aggregation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Aging Skin & Wrinkles?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Aging Skin & Wrinkles
References
- [1] Yuhan Wang et al.. Front Immunol. 2025. Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. doi:10.3389/fimmu.2025.1629288 PubMed
- [2] Mohd Farhan et al.. Pharmaceuticals (Basel). 2024. Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review. doi:10.3390/ph17060670 PubMed
- [3] Xuefei Zhang et al.. Int J Nanomedicine. 2024. Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies. doi:10.2147/IJN.S477820 PubMed
- [4] Qing Wang et al.. Front Pharmacol. 2022. Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. doi:10.3389/fphar.2022.948889 PubMed
- [5] Olagide W Castro et al.. Front Neurol. 2017. Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? doi:10.3389/fneur.2017.00603 PubMed
- [6] Rachel H X Wong et al.. Nutrients. 2016. Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. doi:10.3390/nu8070425 PubMed
- [7] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
- [8] Timothy Mainardi et al.. J Allergy Clin Immunol. 2009. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. doi:10.1016/j.jaci.2008.12.023 PubMed
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