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Astaxanthin ： Aging Skin & Wrinkles

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A meta-analysis of 11 RCTs found oral astaxanthin (3-6 mg/day) significantly improved skin moisture, elasticity, and reduced wrinkle depth. Unique membrane-spanning antioxidant protection.

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結論

            
            
A meta-analysis of 11 RCTs found oral astaxanthin (3-6 mg/day) significantly improved skin moisture, elasticity, and reduced wrinkle depth. Unique membrane-spanning antioxidant protection.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: systematic review of carotenoids for antiaging (nutraceutical, pharmaceutical, cosmeceutical)

            
        

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Skin health outcomes
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Adults (skin health)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=23
                
                
                10 weeks
                
                
                Double-blind
                
            

            
                The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled …
            
            

                
                Dose: 4 mg/day astaxanthin
                
                
                vs: Placebo
                
                
                Outcome: Minimal erythema dose (MED), skin moisture
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Healthy Japanese adults

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
11

        
研究数

    

    

        
650

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Pharmaceuticals (Basel, Switzerland)
                        2025
                        
                        28 件の引用
                        
                    

                

                
                

                    

                        
                            Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Journal of dietary …
                        2021
                        
                        46 件の引用
                        
                    

                

                
                

                    

                        
                            Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2018
                        
                        375 件の引用
                        
                    

                

                
                

                    

                        
                            The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2018
                        
                        113 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
4-12 mg/day

                    

                    
                    

                        
skinhealth:

                        
4-6 mg/day

                    

                    
                

                
                

                    上限量： Generally recognized as safe up to 24 mg/day
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                4 mg/day astaxanthin
                                10 weeks
                                
                                    
                                    Positive
                                    
                                
                                23
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals containing fat for better absorption
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild orange skin discoloration at very high doses (harmless)
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare gastrointestinal discomfort
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Antihypertensive medications (may have additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            Immunosuppressants (may modulate immune function)
                        
    • 
                        
                        
  • 
                            ●
                            5-alpha-reductase inhibitors (theoretical interaction)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Generally recognized as safe up to 24 mg/day
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Astaxanthin help with Aging Skin & Wrinkles?
            
        
        

            Based on 11 studies with 650 participants, there is moderate evidence from clinical studies that Astaxanthin may support Aging Skin & Wrinkles management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Astaxanthin should I take for Aging Skin & Wrinkles?
            
        
        

            Studies have used various dosages. A commonly studied range is 4-12 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Astaxanthin?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild orange skin discoloration at very high doses (harmless), Rare gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Astaxanthin and Aging Skin & Wrinkles?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 650 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Astaxanthin 他の症状・状態について

                    

                        
                        
                            UV Protection (Internal Photoprotection)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Mariia Shanaida et al..
      Pharmaceuticals (Basel).
      2025.
      Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
      doi:10.3390/ph18030403
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Qin Xiang Ng et al..
      J Diet Suppl.
      2021.
      Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies.
      doi:10.1080/19390211.2020.1739187
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sergio Davinelli et al..
      Nutrients.
      2018.
      Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review.
      doi:10.3390/nu10040522
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Naoki Ito et al..
      Nutrients.
      2018.
      The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
      doi:10.3390/nu10070817
      PubMed
    
    5. 
    
  















    

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