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Elastin ： Aging Skin & Wrinkles

D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。

Preliminary evidence from small studies suggests oral elastin peptides may improve skin elasticity. Very early research — topical applications have more data.

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            D

        

        

            
結論

            
            
Preliminary evidence from small studies suggests oral elastin peptides may improve skin elasticity. Very early research — topical applications have more data.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    animal study
                
                
                
                
            

            
                A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and …
            
            

                
                Dose: three-layered bioactive skin substitute (BT Skin) containing collagen type I, agarose, dermatan sulf
                
                
                vs: Placebo
                
                
                
                効果: None
                
                
                None
                
            

            
        

        
        

            

                
                    In Vitro
                
                
                
                5 weeks
                
                
            

            
                Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing …
            
            

                
                Dose: versican V3 or antisense expression
                
                
                vs: control cultures
                
                
                Outcome: insoluble elastin deposition in cultured skin
                
                
                効果: increased elastin aggregates and tissue stiffness
                
                
                None
                
            

            
            
対象集団: Cultured human skin (dermal fibroblasts)

            
        

        
        

            

                
                    In Vitro
                
                
                
                3 weeks
                
                
            

            
                A new dermal equivalent: the use of dermal fibroblast culture alone without exogenous materials.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: A new dermal equivalent: the use of dermal …
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
研究数

    

    

        
100

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        D

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Materials today. Bio
                        2025
                        
                        10 件の引用
                        
                    

                

                
                

                    

                        
                            Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of tissue …
                        2017
                        
                        12 件の引用
                        
                    

                

                
                

                    

                        
                            A new dermal equivalent: the use of dermal fibroblast culture alone without exogenous materials.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of dermatological …
                        2006
                        
                        39 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
75-100 mg/day elastin peptides

                    

                    
                

                
                

                    上限量： Not established
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                three-layered bioactive skin substitute (BT Skin) containing collagen type I, agarose, dermatan sulf
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                versican V3 or antisense expression
                                5 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                3 weeks
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare gastrointestinal discomfort
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            No significant drug interactions documented
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Not established
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Elastin help with Aging Skin & Wrinkles?
            
        
        

            Based on 2 studies with 100 participants, there is preliminary evidence that needs more research that Elastin may support Aging Skin & Wrinkles management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much Elastin should I take for Aging Skin & Wrinkles?
            
        
        

            Studies have used various dosages. A commonly studied range is 75-100 mg/day elastin peptides. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Elastin?
            
        
        

            Reported side effects may include Generally well-tolerated, Rare gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Elastin and Aging Skin & Wrinkles?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Carlos Chocarro-Wrona et al..
      Mater Today Bio.
      2025.
      A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration.
      doi:10.1016/j.mtbio.2025.101592
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Mervyn J Merrilees et al..
      J Tissue Eng Regen Med.
      2017.
      Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin.
      doi:10.1002/term.1913
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Dong-Youn Lee et al..
      J Dermatol Sci.
      2006.
      A new dermal equivalent: the use of dermal fibroblast culture alone without exogenous materials.
      doi:10.1016/j.jdermsci.2006.03.007
      PubMed
    
    4. 
    
  















    

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