Turmeric (Curcumin)Turmeric (Curcumin)
herb
别名: Curcumin, Curcuma longa, Turmeric Extract, Curcuminoids
About
Curcumin is one of the most studied anti-inflammatory compounds, with demonstrated NF-kB inhibition relevant to psoriasis, acne, and inflammatory skin conditions. The major limitation is oral bioavailability (< 1%); formulations with piperine increase absorption by 2,000%. A pilot study found curcumin may help support skin health in psoriasis.
How It Works
Active polyphenol curcumin inhibits NF-kB, AP-1, and STAT3 inflammatory signaling pathways; modulates COX-2 and LOX enzymes; may inhibit tyrosinase for depigmentation effects; antioxidant properties protect against oxidative stress in skin; low oral bioavailability (~1%) improved by piperine or lipid formulations.
Evidence For Conditions
Side Effects
- Gastrointestinal discomfort (nausea, diarrhea)
- Yellow staining of teeth (powder form)
- May worsen gallbladder conditions
Drug & Supplement Interactions
- Anticoagulants (may increase bleeding risk)
- Antidiabetic medications (may enhance blood sugar lowering)
- CYP450 substrates (may inhibit drug metabolism)
- Iron supplements (may reduce absorption)
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Related Ingredients
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