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Polypodium leucotomos 用于 紫外线防护（内源性光防护）

B 证据 至少一项随机试验支持这一结论，结果基本一致。

A systematic review found oral PLE significantly increased MED by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

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            B

        

        

            
结论

            
            
A systematic review found oral PLE significantly increased MED by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Oral Supplements and Photoprotection: A Systematic Review.
            
            

                
                Dose: None
                
                
                vs: Placebo/no supplement
                
                
                Outcome: Photoprotective effects (MED, erythema)
                
                
                效果: None
                
                
                None
                
            

            
            
研究人群: Healthy adults (47 studies in systematic review)

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
研究数量

    

    

        
250

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Oral Supplements and Photoprotection: A Systematic Review.
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Journal of medicinal …
                        2025
                        
                        3 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
240-480 mg/day

                    

                    
                    

                        
photoprotection:

                        
480 mg/day (240 mg twice daily, 30-60 min before sun exposure)

                    

                    
                

                
                

                    上限： Generally well-tolerated up to 960 mg/day
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： 30-60 minutes before sun exposure; can also be taken daily for baseline protection
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Pruritus (rare)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Immunosuppressants (may modulate immune function)
                        
    • 
                        
                        
  • 
                            ●
                            Photosensitizing medications (may modulate UV response)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Generally well-tolerated up to 960 mg/day
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Polypodium leucotomos help with 紫外线防护（内源性光防护）?
            
        
        

            Based on 5 studies with 250 participants, there is moderate evidence from clinical studies that Polypodium leucotomos may support 紫外线防护（内源性光防护） management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Polypodium leucotomos should I take for 紫外线防护（内源性光防护）?
            
        
        

            Studies have used various dosages. A commonly studied range is 240-480 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Polypodium leucotomos?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort (rare), Pruritus (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Polypodium leucotomos and 紫外线防护（内源性光防护）?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Polypodium leucotomos 用于其他健康状况

                    

                        
                        
                            色素沉着过度
                            C

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Nicole Natarelli et al..
      J Med Food.
      2025.
      Oral Supplements and Photoprotection: A Systematic Review.
      doi:10.1089/jmf.2024.0023
      PubMed
    
    2. 
    
  















    

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