Niacinamide pour UV Protection (Internal Photoprotection)
A Preuves Plusieurs grands essais cliniques montrent de manière constante des bénéfices significatifs.The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.
En conclusion
The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.
Key Study Findings
Population: Overview of reviews on niacin/nicotinamide adverse effects
Population: High-risk NMSC patients (RCTs)
Population: None
Key Statistics
5
Études
686
Participants
Positive
Note
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 14-16 mg/day NE (RDA)
- skinhealth:
- 500-1,500 mg/day oral nicotinamide
Limite supérieure : 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. | 26 weeks | Positive | -- |
| Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) | -- | Positive | -- |
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
Moment optimal de prise : With meals; can be split into 2-3 doses
Safety & Side Effects
Effets indésirables signalés
- ⚠ Generally well-tolerated (no flushing unlike niacin)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)
Interactions connues
- ● Anticonvulsants (carbamazepine — may increase niacinamide levels)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
- ● Isoniazid (competes for NAD+ pathways)
Apport maximal tolérable : 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Niacinamide help with UV Protection (Internal Photoprotection)?
How much Niacinamide should I take for UV Protection (Internal Photoprotection)?
Are there side effects of Niacinamide?
How strong is the evidence for Niacinamide and UV Protection (Internal Photoprotection)?
Related Evidence
Autres ingrédients pour UV Protection (Internal Photoprotection)
Niacinamide pour d'autres pathologies
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
- [3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
- [4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.