Niacinamide untuk UV Protection (Internal Photoprotection)

A Bukti Beberapa uji klinis besar secara konsisten menunjukkan manfaat yang signifikan.

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.

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Kesimpulan

Key Study Findings

laboratory/in vitro 26 weeks

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.

Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. vs: Placebo Efek: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo None

review

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.

Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) vs: Placebo Efek: None None

Review

The adverse effects of oral niacin/nicotinamide - an overview of reviews.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Overview of reviews on niacin/nicotinamide adverse effects

Meta-Analysis

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.

Dose: Nicotinamide (vitamin B3) vs: Placebo Outcome: AK and NMSC incidence reduction Efek: None None

Populasi: High-risk NMSC patients (RCTs)

Review

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …

Dose: None vs: Placebo Efek: None None

Other

Nicotinamide: An Update and Review of Safety & Differences from Niacin.

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Key Statistics

Studi

686

Peserta

↑

Positive

Peringkat

Referenced Papers

The adverse effects of oral niacin/nicotinamide - an overview of reviews. Review

Eye (London, England) 2025 1 sitasi

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. Other

International journal of … 2025

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. Review

International journal for … 2025

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2023 16 sitasi

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. Review

Journal of the … 2021 46 sitasi

Nicotinamide: An Update and Review of Safety & Differences from Niacin. Other

Skin therapy letter 2020 13 sitasi

Final report of the safety assessment of niacinamide and niacin. Review

International journal of … 2005 22 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 14-16 mg/day NE (RDA)
skinhealth:: 500-1,500 mg/day oral nicotinamide

Batas atas: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.	26 weeks	Positive	--
Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)	--	Positive	--
None	--	Mixed	--
Nicotinamide (vitamin B3)	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Niacinamide up to 5%; Niacin up to 0.1%	--	Mixed	--

Waktu terbaik diminum: With meals; can be split into 2-3 doses

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Generally well-tolerated (no flushing unlike niacin)
⚠ Mild gastrointestinal discomfort at high doses
⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Interaksi yang Diketahui

● Anticonvulsants (carbamazepine — may increase niacinamide levels)
● Hepatotoxic drugs (potential additive liver effect at high doses)
● Isoniazid (competes for NAD+ pathways)

Asupan atas yang dapat ditoleransi: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Niacinamide help with UV Protection (Internal Photoprotection)?

Based on 5 studies with 686 participants, there is strong evidence from multiple clinical trials that Niacinamide may support UV Protection (Internal Photoprotection) management. Our evidence grade is A (Strong Evidence).

How much Niacinamide should I take for UV Protection (Internal Photoprotection)?

Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Niacinamide?

Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Niacinamide and UV Protection (Internal Photoprotection)?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 5 peer-reviewed studies with 686 total participants. The overall direction of effect is positive.

Bahan lain untuk UV Protection (Internal Photoprotection)

Nicotinamide A Omega-3 Fatty Acids B Green Tea Extract B Astaxanthin B Polypodium leucotomos B Vitamin E C

Niacinamide untuk kondisi lain

Acne A

Kesimpulan Singkat

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA …

Evidence Strength92%

High confidence

Rincian Studi

RCT (0)Meta (1)Other (4)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk UV Protection (Internal Photoprotection)

Pelajari Lebih Lanjut

References

[1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
[2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
[3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
[4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
[5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
[6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
[7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed

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