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Omega-3 Fatty Acids untuk UV Protection (Internal Photoprotection)

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Research suggests omega-3 supplementation may increase the skin's minimal erythema dose (MED), potentially providing a modest photoprotective effect through anti-inflammatory mechanisms.

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Kesimpulan

            
            
Research suggests omega-3 supplementation may increase the skin's minimal erythema dose (MED), potentially providing a modest photoprotective effect through anti-inflammatory mechanisms.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: Patients with acne, HS, or psoriasis

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: None

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: review of naturally derived bioactive compounds for psoriasis (flavonoids, terpenoids, omega-3, alkaloids)

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                12 weeks
                
                
                Open-label
                
            

            
                Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized …
            
            

                
                Dose: Mediterranean diet
                
                
                vs: Standard diet
                
                
                Outcome: HDL/LDL subfractions and metabolic syndrome
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: Patients with psoriatic arthritis

            
        

        
        

            

                
                    narrative_review
                
                
                
                
            

            
                Nutrition and skin: Kids are not just little people.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efek: narrative review; discusses role of nutrition from prenatal period on skin immune responses; highlig
                
                
                not_applicable
                
            

            
        

        
        

            

                
                    Other
                
                
                
                
            

            
                In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular …
            
            

                
                Dose: 100 mg
                
                
                vs: control
                
                
                Outcome: None
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: psoriasis patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
8

        
Studi

    

    

        
400

        
Peserta

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Peringkat

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Inflammopharmacology
                        2025
                        
                        26 sitasi
                        
                    

                

                
                

                    

                        
                            Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), …
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Current obesity reports
                        2025
                        
                    

                

                
                

                    

                        
                            Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2025
                        
                    

                

                
                

                    

                        
                            Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Advances in rheumatology …
                        2024
                        
                    

                

                
                

                    

                        
                            Role of nutritional supplements in selected dermatological disorders: A review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of cosmetic …
                        2022
                        
                        30 sitasi
                        
                    

                

                
                

                    

                        
                            Nutrition and skin: Kids are not just little people.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Clinics in dermatology
                        2016
                        
                        19 sitasi
                        
                    

                

                
                

                    

                        
                            In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular markers and macrophages.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        FEBS open bio
                        2016
                        
                        1 sitasi
                        
                    

                

                
                

                    

                        
                            Dietary supplements for established atopic eczema.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        The Cochrane database …
                        2012
                        
                        130 sitasi
                        
                    

                

                
                

                    

                        
                            Complementary, holistic, and integrative medicine: Crohn disease.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Pediatrics in review
                        2012
                        
                    

                

                
                

                    

                        
                            OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Circulation
                        2010
                        
                        593 sitasi
                        
                    

                

                
                

                    

                        
                            Omega-3 fatty acids in health and disease and in growth and development.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        The American journal …
                        1991
                        
                        2278 sitasi
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosis yang Umum Digunakan

                

                    
                    

                        
general:

                        
250-500 mg combined EPA/DHA per day

                    

                    
                    

                        
skinhealth:

                        
1,000-2,000 mg/day EPA+DHA

                    

                    
                

                
                

                    Batas atas: 3,000 mg/day combined EPA/DHA (FDA GRAS)
                

                
            

            

            
            

                
Dosis yang Diteliti dalam Penelitian

                

                    

                        
                            

                                Dosis
                                Durasi
                                Efek
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                Mediterranean diet
                                12 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                100 mg
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Waktu terbaik diminum: With meals containing fat for better absorption
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efek Samping yang Dilaporkan

                    
    
                        
                        
  • 
                            ⚠
                            Fishy aftertaste or burping
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential increased bleeding time at very high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            May lower blood pressure slightly
                        
    • 
                        
                    

                

                

                
                

                    
Interaksi yang Diketahui

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Orlistat (may reduce omega-3 absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Asupan atas yang dapat ditoleransi: 3,000 mg/day combined EPA/DHA (FDA GRAS)
                    

                

                
            

            

                Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Omega-3 Fatty Acids help with UV Protection (Internal Photoprotection)?
            
        
        

            Based on 8 studies with 400 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids may support UV Protection (Internal Photoprotection) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Omega-3 Fatty Acids should I take for UV Protection (Internal Photoprotection)?
            
        
        

            Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Omega-3 Fatty Acids?
            
        
        

            Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Omega-3 Fatty Acids and UV Protection (Internal Photoprotection)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Ada Radu et al..
      Inflammopharmacology.
      2025.
      Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.
      doi:10.1007/s10787-024-01602-z
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Luigi Barrea et al..
      Curr Obes Rep.
      2025.
      Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), …
      doi:10.1007/s13679-025-00630-2
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Pilar Zafrilla et al..
      Nutrients.
      2025.
      Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
      doi:10.3390/nu17223506
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Daniele Scherer et al..
      Adv Rheumatol.
      2024.
      Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial.
      doi:10.1186/s42358-024-00389-5
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Kabir Sardana et al..
      J Cosmet Dermatol.
      2022.
      Role of nutritional supplements in selected dermatological disorders: A review.
      doi:10.1111/jocd.14436
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Meagen McCusker et al..
      Clin Dermatol.
      2016.
      Nutrition and skin: Kids are not just little people.
      doi:10.1016/j.clindermatol.2016.07.004
      PubMed
    
    7. 
    
    
  7. 
      [7]
      Mohd Hanif Zulfakar et al..
      FEBS Open Bio.
      2016.
      In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular markers and macrophages.
      doi:10.1002/2211-5463.12095
      PubMed
    
    8. 
    
    
  8. 
      [8]
      Fiona J Bath-Hextall et al..
      Cochrane Database Syst Rev.
      2012.
      Dietary supplements for established atopic eczema.
      doi:10.1002/14651858.CD005205.pub3
      PubMed
    
    9. 
    
    
  9. 
      [9]
      Alycia Leiby et al..
      Pediatr Rev.
      2012.
      Complementary, holistic, and integrative medicine: Crohn disease.
      doi:10.1542/pir.33-2-83
      PubMed
    
    10. 
    
    
  10. 
      [10]
      Bernhard Rauch et al..
      Circulation.
      2010.
      OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted …
      doi:10.1161/CIRCULATIONAHA.110.948562
      PubMed
    
    11. 
    
    
  11. 
      [11]
      A P Simopoulos.
      Am J Clin Nutr.
      1991.
      Omega-3 fatty acids in health and disease and in growth and development.
      doi:10.1093/ajcn/54.3.438
      PubMed
    
    12. 
    
  















    

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