Nicotinamide pour UV Protection (Internal Photoprotection)
A Preuves Plusieurs grands essais cliniques montrent de manière constante des bénéfices significatifs.At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).
En conclusion
At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).
Key Study Findings
Population: Overview of reviews on niacin/nicotinamide adverse effects
Population: High-risk NMSC patients (RCTs)
Population: None
Population: General population (cosmetic users)
Key Statistics
5
Études
686
Participants
Positive
Note
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- generalskinbarrier:
- 500-1,500 mg/day
- skincancerchemoprevention:
- 500 mg twice daily (1,000 mg/day total)
Limite supérieure : Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
Moment optimal de prise : With meals; split into 2 doses for chemoprevention
Safety & Side Effects
Effets indésirables signalés
- ⚠ Generally well-tolerated (no flushing)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses
Interactions connues
- ● Anticonvulsants (carbamazepine — may increase levels)
- ● Isoniazid (competes for NAD+ pathways)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
Apport maximal tolérable : Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Nicotinamide help with UV Protection (Internal Photoprotection)?
How much Nicotinamide should I take for UV Protection (Internal Photoprotection)?
Are there side effects of Nicotinamide?
How strong is the evidence for Nicotinamide and UV Protection (Internal Photoprotection)?
Related Evidence
Autres ingrédients pour UV Protection (Internal Photoprotection)
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [3] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [4] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [5] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.