What is the recommended dosage for Alpha-Lipoic Acid?

General: 300-600 mg/day; Skin Health: 300-600 mg/day (R-lipoic acid is more bioactive)

What are the side effects of Alpha-Lipoic Acid?

Potential side effects include: Nausea, Skin rash (rare), Hypoglycemia (may lower blood sugar).

What is alpha-lipoic acid and how may it support skin health?

Alpha-lipoic acid (ALA) is a sulfur-containing antioxidant that functions in both water and fat-soluble environments, making it effective throughout skin tissue. It regenerates other antioxidants including vitamins C and E. ALA has been studied for anti-aging skin effects including reduction of fine lines and improved skin texture.

What dosage of alpha-lipoic acid has been studied for skin benefits?

Skin-related studies have used 300–600 mg of alpha-lipoic acid per day orally, typically for 8–12 weeks. The R-enantiomer is considered the more biologically active form. Topical ALA studies have used 1–5% concentrations. Oral bioavailability is approximately 30% and is reduced by food.

What are the potential side effects of alpha-lipoic acid?

Common side effects include nausea, skin rash, and digestive discomfort. ALA may lower blood sugar and should be used cautiously with diabetes medications. A rare but serious side effect is insulin autoimmune syndrome, particularly reported in Japanese populations. Very high doses may have pro-oxidant effects.

Alpha-Lipoic Acid
Alpha-Lipoic Acid

antioxidant

别名: ALA, Thioctic Acid, R-Lipoic Acid, R-ALA

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About

Alpha-lipoic acid is a universal antioxidant soluble in both water and fat, capable of regenerating vitamins C and E and glutathione. A clinical study found oral ALA (300 mg/day for 12 weeks) reduced facial wrinkles, roughness, and improved skin texture in women.

How It Works

Universal antioxidant soluble in both water and fat; chelates metal ions and regenerates vitamins C and E and glutathione; may inhibit NF-kB activation and MMP expression in UV-exposed skin; supports mitochondrial energy production in aging fibroblasts.

Evidence For Conditions

健康状况	等级	研究数量	受试者
Aging Skin & Wrinkles	C	4	200	查看 →

Side Effects

Nausea
Skin rash (rare)
Hypoglycemia (may lower blood sugar)

Drug & Supplement Interactions

Antidiabetic medications (may enhance blood sugar lowering — monitor glucose)
Thyroid medications (may affect thyroid hormone levels)
Chemotherapy agents (consult oncologist)

请务必告知您的医疗保健提供者您正在服用的所有补充剂。

Related Ingredients

Astaxanthin Glutathione Resveratrol CoQ10

速览

剂量: General: 300-600 mg/day; Skin_Health: 300-600 mg/day (R-lipoic acid is more bioactive)
剂型: capsule tablet liquid
天然来源: Red meat, Organ meats, Broccoli, Spinach, Tomatoes, Brussels sprouts, Yeast
上限: Generally well-tolerated up to 1,800 mg/day
最佳时间: On an empty stomach (food reduces bioavailability by ~30%); 30 minutes before meals

证据摘要

Aging Skin & Wrinkles C

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