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Omega-3 Fatty Acids 用于 湿疹（特应性皮炎）

B 证据 至少一项随机试验支持这一结论，结果基本一致。

A meta-analysis suggested fish oil supplementation (EPA/DHA 1-4 g/day) is associated with modest improvements in eczema severity scores, possibly through anti-inflammatory eicosanoid modulation.

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            B

        

        

            
结论

            
            
A meta-analysis suggested fish oil supplementation (EPA/DHA 1-4 g/day) is associated with modest improvements in eczema severity scores, possibly through anti-inflammatory eicosanoid modulation.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    narrative_review
                
                
                
                
            

            
                Nutrition and skin: Kids are not just little people.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                效果: narrative review; discusses role of nutrition from prenatal period on skin immune responses; highlig
                
                
                not_applicable
                
            

            
        

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                Dietary supplements for established atopic eczema.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Atopic eczema severity
                
                
                效果: None
                
                
                None
                
            

            
            
研究人群: Adults and children with established atopic eczema

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
14

        
研究数量

    

    

        
1200

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Role of nutritional supplements in selected dermatological disorders: A review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of cosmetic …
                        2022
                        
                        30 次引用
                        
                    

                

                
                

                    

                        
                            Nutrition and skin: Kids are not just little people.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Clinics in dermatology
                        2016
                        
                        19 次引用
                        
                    

                

                
                

                    

                        
                            Dietary supplements for established atopic eczema.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        The Cochrane database …
                        2012
                        
                        130 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
250-500 mg combined EPA/DHA per day

                    

                    
                    

                        
skinhealth:

                        
1,000-2,000 mg/day EPA+DHA

                    

                    
                

                
                

                    上限： 3,000 mg/day combined EPA/DHA (FDA GRAS)
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： With meals containing fat for better absorption
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Fishy aftertaste or burping
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Potential increased bleeding time at very high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            May lower blood pressure slightly
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Orlistat (may reduce omega-3 absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： 3,000 mg/day combined EPA/DHA (FDA GRAS)
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Omega-3 Fatty Acids help with 湿疹（特应性皮炎）?
            
        
        

            Based on 14 studies with 1,200 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids may support 湿疹（特应性皮炎） management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Omega-3 Fatty Acids should I take for 湿疹（特应性皮炎）?
            
        
        

            Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Omega-3 Fatty Acids?
            
        
        

            Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Omega-3 Fatty Acids and 湿疹（特应性皮炎）?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 14 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                
                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Kabir Sardana et al..
      J Cosmet Dermatol.
      2022.
      Role of nutritional supplements in selected dermatological disorders: A review.
      doi:10.1111/jocd.14436
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Meagen McCusker et al..
      Clin Dermatol.
      2016.
      Nutrition and skin: Kids are not just little people.
      doi:10.1016/j.clindermatol.2016.07.004
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Fiona J Bath-Hextall et al..
      Cochrane Database Syst Rev.
      2012.
      Dietary supplements for established atopic eczema.
      doi:10.1002/14651858.CD005205.pub3
      PubMed
    
    4. 
    
  















    

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