Omega-3 Fatty Acids 用于 银屑病
D 研究 目前仅存在初步研究（实验室研究、病例报告）。Some RCTs suggest omega-3 supplementation may modestly improve psoriasis severity through anti-inflammatory effects, but results are inconsistent across trials.
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D
结论
Some RCTs suggest omega-3 supplementation may modestly improve psoriasis severity through anti-inflammatory effects, but results are inconsistent across trials.
Key Study Findings
Review
Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of naturally derived bioactive compounds for psoriasis (flavonoids, terpenoids, omega-3, alkaloids)
Review
Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Patients with acne, HS, or psoriasis
Review
Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian …
Dose: None
vs: None
Outcome: Colitis severity
效果: None
None
研究人群: Crohn's disease patients
narrative_review
Nutrition and skin: Kids are not just little people.
Dose: None
vs: Placebo
效果: narrative review; discusses role of nutrition from prenatal period on skin immune responses; highlig
not_applicable
Other
In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular …
Dose: 100 mg
vs: control
Outcome: None
效果: None
None
研究人群: psoriasis patients
Review
Diet and psoriasis, part III: role of nutritional supplements.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: psoriasis patients
Key Statistics
6
研究数量
400
受试者
↑
Positive
D
等级
Referenced Papers
Inflammopharmacology
2025
26 次引用
Current obesity reports
2025
Autoimmunity reviews
2024
12 次引用
Journal of cosmetic …
2022
30 次引用
Clinics in dermatology
2016
19 次引用
FEBS open bio
2016
1 次引用
Journal of the …
2014
93 次引用
Current atherosclerosis reports
2004
464 次引用
Journal of the …
2002
2016 次引用
Drugs
1998
99 次引用
Arquivos de gastroenterologia
1996
The American journal …
1991
2278 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 250-500 mg combined EPA/DHA per day
- skinhealth:
- 1,000-2,000 mg/day EPA+DHA
上限： 3,000 mg/day combined EPA/DHA (FDA GRAS)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| 100 mg | -- | Mixed | -- |
| None | -- | Positive | -- |
| EPA and DHA | -- | Positive | -- |
| Omega-3 fatty acids (EPA, DHA) | -- | Positive | -- |
最佳服用时间： With meals containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Fishy aftertaste or burping
- ⚠ Mild gastrointestinal discomfort
- ⚠ Potential increased bleeding time at very high doses
- ⚠ May lower blood pressure slightly
已知相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
- ● Blood pressure medications (additive hypotensive effect)
- ● Orlistat (may reduce omega-3 absorption)
可耐受最高摄入量： 3,000 mg/day combined EPA/DHA (FDA GRAS)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Omega-3 Fatty Acids help with 银屑病?
Based on 6 studies with 400 participants, there is preliminary evidence that needs more research that Omega-3 Fatty Acids may support 银屑病 management. Our evidence grade is D (Very Early Research).
How much Omega-3 Fatty Acids should I take for 银屑病?
Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids and 银屑病?
We rate the evidence as Grade D (Very Early Research). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 银屑病
Omega-3 Fatty Acids 用于其他健康状况
References
- [1] Ada Radu et al.. Inflammopharmacology. 2025. Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions. doi:10.1007/s10787-024-01602-z PubMed
- [2] Luigi Barrea et al.. Curr Obes Rep. 2025. Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), … doi:10.1007/s13679-025-00630-2 PubMed
- [3] Kimsor Hong et al.. Autoimmun Rev. 2024. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. doi:10.1016/j.autrev.2024.103651 PubMed
- [4] Kabir Sardana et al.. J Cosmet Dermatol. 2022. Role of nutritional supplements in selected dermatological disorders: A review. doi:10.1111/jocd.14436 PubMed
- [5] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [6] Mohd Hanif Zulfakar et al.. FEBS Open Bio. 2016. In vivo response of GsdmA3(Dfl)/+ mice to topically applied fish oil - effects on cellular markers and macrophages. doi:10.1002/2211-5463.12095 PubMed
- [7] Jillian W Millsop et al.. J Am Acad Dermatol. 2014. Diet and psoriasis, part III: role of nutritional supplements. doi:10.1016/j.jaad.2014.03.016 PubMed
- [8] Trevor A Mori et al.. Curr Atheroscler Rep. 2004. Omega-3 fatty acids and inflammation. doi:10.1007/s11883-004-0087-5 PubMed
- [9] Artemis P Simopoulos. J Am Coll Nutr. 2002. Omega-3 fatty acids in inflammation and autoimmune diseases. doi:10.1080/07315724.2002.10719248 PubMed
- [10] A Heller et al.. Drugs. 1998. Lipid mediators in inflammatory disorders. doi:10.2165/00003495-199855040-00001 PubMed
- [11] C Cukier et al.. Arq Gastroenterol. 1996. [Biological activity of fish oil]. PubMed
- [12] A P Simopoulos. Am J Clin Nutr. 1991. Omega-3 fatty acids in health and disease and in growth and development. doi:10.1093/ajcn/54.3.438 PubMed
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