Glutathione 用于色素沉着过度

C 证据来自小型研究的证据有限，但存在一些积极信号。

Multiple small RCTs found oral glutathione (250-1,000 mg/day) may reduce melanin index through tyrosinase inhibition and melanin pathway modulation, primarily studied in Asian populations.

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结论

Multiple small RCTs found oral glutathione (250-1,000 mg/day) may reduce melanin index through tyrosinase inhibition and melanin pathway modulation, primarily studied in Asian populations.

Key Study Findings

Other

Milk Fat Globules: 2024 Updates.

Dose: None vs: None Outcome: Inflammatory markers 效果: None None

研究人群: None

RCT n=24 4 weeks Double-blind

Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs.

Dose: 500 mg d-ribose-l-cysteine (RibCys) every 12 hours vs: Placebo 效果: None None

Review

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Dose: None vs: None Outcome: Role of oxidative stress in atopic dermatitis 效果: None None

研究人群: Patients with atopic dermatitis

Review

The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.

Dose: None vs: None Outcome: antioxidant status 效果: None None

研究人群: None

Case-Control n=26

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to …

Dose: None vs: Healthy controls (n=11) Outcome: Oxidative stress and muscle dysfunction during exercise 效果: Enhanced oxidative stress with early TBARS and RAA changes None

研究人群: 15 CFS patients vs 11 healthy matched controls

In Vitro

N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts.

Dose: N-acetyl-L-cysteine (NAC) vs: UV-irradiated cells without NAC Outcome: DNA damage prevention from UV radiation 效果: NAC prevented DNA damage induced by UVA, UVB, UVC None

研究人群: Cultured human cells

Key Statistics

研究数量

350

受试者

↑

Positive

等级

Referenced Papers

Milk Fat Globules: 2024 Updates. Other

Newborn (Clarksville, Md.) 2024 9 次引用

Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs. RCT

American journal of … 2021 2 次引用

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 次引用

The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. Review

International journal of … 2011 73 次引用

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. Other

Journal of internal … 2005 197 次引用

N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. Other

Journal of photochemistry … 2003 71 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 250-1,000 mg/day
skinlightening:: 500-1,000 mg/day

上限： Not established; generally well-tolerated up to 1,000 mg/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
500 mg d-ribose-l-cysteine (RibCys) every 12 hours	4 weeks	Neutral	24
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	26
N-acetyl-L-cysteine (NAC)	--	Positive	--

最佳服用时间： On an empty stomach for better absorption; liposomal forms have improved bioavailability

Safety & Side Effects

已报告的副作用

⚠ Generally well-tolerated
⚠ Mild bloating or gastrointestinal discomfort
⚠ Rare skin rash

已知相互作用

● Chemotherapy agents (may interfere — consult oncologist)
● Acetaminophen (glutathione is involved in its detoxification)

可耐受最高摄入量： Not established; generally well-tolerated up to 1,000 mg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Glutathione help with 色素沉着过度?

Based on 6 studies with 350 participants, there is limited but promising evidence that Glutathione may support 色素沉着过度 management. Our evidence grade is C (Some Evidence).

How much Glutathione should I take for 色素沉着过度?

Studies have used various dosages. A commonly studied range is 250-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Glutathione?

Reported side effects may include Generally well-tolerated, Mild bloating or gastrointestinal discomfort, Rare skin rash. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Glutathione and 色素沉着过度?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

其他成分用于色素沉着过度

Pine Bark Extract (Pycnogenol) C Polypodium leucotomos C Grape Seed Extract C N-Acetyl Cysteine C

快速结论

Multiple small RCTs found oral glutathione (250-1,000 mg/day) may reduce melanin index through tyrosinase inhibition and melanin pathway modulation, primarily studied in Asian populations.

Evidence Strength52%

Moderate confidence

研究分析

RCT (1)Meta (0)Other (5)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于色素沉着过度

了解更多

References

[1] Akhil Maheshwari et al.. Newborn (Clarksville). 2024. Milk Fat Globules: 2024 Updates. doi:10.5005/jp-journals-11002-0085 PubMed
[2] Ariana M Verrilli et al.. Am J Vet Res. 2021. Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs. doi:10.2460/ajvr.82.8.653 PubMed
[3] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
[4] Chiara De Luca et al.. Int J Environ Res Public Health. 2011. The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. doi:10.3390/ijerph8072770 PubMed
[5] Y Jammes et al.. J Intern Med. 2005. Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. doi:10.1111/j.1365-2796.2005.01452.x PubMed
[6] N Morley et al.. J Photochem Photobiol B. 2003. N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. doi:10.1016/j.jphotobiol.2003.06.004 PubMed

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Glutathione 用于 色素沉着过度

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结论

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

常用剂量

研究中使用的剂量

Safety & Side Effects

已报告的副作用

已知相互作用

Frequently Asked Questions

Related Evidence

其他成分用于 色素沉着过度

References

Glutathione 用于色素沉着过度

其他成分用于色素沉着过度