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Polypodium leucotomos 用于 色素沉着过度

C 证据 来自小型研究的证据有限，但存在一些积极信号。

An RCT found PLE (480 mg/day for 60 days) reduced MASI (melasma severity) scores when used as adjunct to sunscreen. May help support even skin tone via photoprotection.

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            C

        

        

            
结论

            
            
An RCT found PLE (480 mg/day for 60 days) reduced MASI (melasma severity) scores when used as adjunct to sunscreen. May help support even skin tone via photoprotection.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
            
            

                
                Dose: 14 nutritional compounds (vitamins, minerals, etc.)
                
                
                vs: None
                
                
                Outcome: Skin health and barrier function
                
                
                效果: None
                
                
                None
                
            

            
            
研究人群: General population (skin health review)

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
研究数量

    

    

        
150

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
等级

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Medicina (Kaunas, Lithuania)
                        2023
                        
                        41 次引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
240-480 mg/day

                    

                    
                    

                        
photoprotection:

                        
480 mg/day (240 mg twice daily, 30-60 min before sun exposure)

                    

                    
                

                
                

                    上限： Generally well-tolerated up to 960 mg/day
                

                
            

            

            
            

                
研究中使用的剂量

                

                    

                        
                            

                                剂量
                                持续时间
                                效果
                                N
                            

                        
                        
                            
                            

                                14 nutritional compounds (vitamins, minerals, etc.)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                最佳服用时间： 30-60 minutes before sun exposure; can also be taken daily for baseline protection
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Pruritus (rare)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Immunosuppressants (may modulate immune function)
                        
    • 
                        
                        
  • 
                            ●
                            Photosensitizing medications (may modulate UV response)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Generally well-tolerated up to 960 mg/day
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Polypodium leucotomos help with 色素沉着过度?
            
        
        

            Based on 3 studies with 150 participants, there is limited but promising evidence that Polypodium leucotomos may support 色素沉着过度 management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Polypodium leucotomos should I take for 色素沉着过度?
            
        
        

            Studies have used various dosages. A commonly studied range is 240-480 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Polypodium leucotomos?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort (rare), Pruritus (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Polypodium leucotomos and 色素沉着过度?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Polypodium leucotomos 用于其他健康状况

                    

                        
                        
                            紫外线防护（内源性光防护）
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Jacek Januszewski et al..
      Medicina (Kaunas).
      2023.
      Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
      doi:10.3390/medicina60010068
      PubMed
    
    2. 
    
  















    

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