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Glutathione ： Hyperpigmentation

C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

Multiple small RCTs found oral glutathione (250-1,000 mg/day) may reduce melanin index through tyrosinase inhibition and melanin pathway modulation, primarily studied in Asian populations.

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            C

        

        

            
結論

            
            
Multiple small RCTs found oral glutathione (250-1,000 mg/day) may reduce melanin index through tyrosinase inhibition and melanin pathway modulation, primarily studied in Asian populations.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Other
                
                
                
                
            

            
                Milk Fat Globules: 2024 Updates.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Inflammatory markers
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    RCT
                
                
                n=24
                
                
                4 weeks
                
                
                Double-blind
                
            

            
                Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs.
            
            

                
                Dose: 500 mg d-ribose-l-cysteine (RibCys) every 12 hours
                
                
                vs: Placebo
                
                
                
                効果: None
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Role of reactive oxygen species and antioxidants in atopic dermatitis.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Role of oxidative stress in atopic dermatitis
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Patients with atopic dermatitis

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: antioxidant status
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Case-Control
                
                
                n=26
                
                
                
            

            
                Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to …
            
            

                
                Dose: None
                
                
                vs: Healthy controls (n=11)
                
                
                Outcome: Oxidative stress and muscle dysfunction during exercise
                
                
                効果: Enhanced oxidative stress with early TBARS and RAA changes
                
                
                None
                
            

            
            
対象集団: 15 CFS patients vs 11 healthy matched controls

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts.
            
            

                
                Dose: N-acetyl-L-cysteine (NAC)
                
                
                vs: UV-irradiated cells without NAC
                
                
                Outcome: DNA damage prevention from UV radiation
                
                
                効果: NAC prevented DNA damage induced by UVA, UVB, UVC
                
                
                None
                
            

            
            
対象集団: Cultured human cells

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
研究数

    

    

        
350

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Milk Fat Globules: 2024 Updates.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Newborn (Clarksville, Md.)
                        2024
                        
                        9 件の引用
                        
                    

                

                
                

                    

                        
                            Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        American journal of …
                        2021
                        
                        2 件の引用
                        
                    

                

                
                

                    

                        
                            Role of reactive oxygen species and antioxidants in atopic dermatitis.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2013
                        
                        178 件の引用
                        
                    

                

                
                

                    

                        
                            The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2011
                        
                        73 件の引用
                        
                    

                

                
                

                    

                        
                            Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of internal …
                        2005
                        
                        197 件の引用
                        
                    

                

                
                

                    

                        
                            N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of photochemistry …
                        2003
                        
                        71 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
general:

                        
250-1,000 mg/day

                    

                    
                    

                        
skinlightening:

                        
500-1,000 mg/day

                    

                    
                

                
                

                    上限量： Not established; generally well-tolerated up to 1,000 mg/day
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                500 mg d-ribose-l-cysteine (RibCys) every 12 hours
                                4 weeks
                                
                                    
                                    Neutral
                                    
                                
                                24
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                26
                            

                            
                            

                                N-acetyl-L-cysteine (NAC)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： On an empty stomach for better absorption; liposomal forms have improved bioavailability
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild bloating or gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare skin rash
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Chemotherapy agents (may interfere — consult oncologist)
                        
    • 
                        
                        
  • 
                            ●
                            Acetaminophen (glutathione is involved in its detoxification)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Not established; generally well-tolerated up to 1,000 mg/day
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Glutathione help with Hyperpigmentation?
            
        
        

            Based on 6 studies with 350 participants, there is limited but promising evidence that Glutathione may support Hyperpigmentation management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Glutathione should I take for Hyperpigmentation?
            
        
        

            Studies have used various dosages. A commonly studied range is 250-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Glutathione?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild bloating or gastrointestinal discomfort, Rare skin rash. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Glutathione and Hyperpigmentation?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Akhil Maheshwari et al..
      Newborn (Clarksville).
      2024.
      Milk Fat Globules: 2024 Updates.
      doi:10.5005/jp-journals-11002-0085
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Ariana M Verrilli et al..
      Am J Vet Res.
      2021.
      Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs.
      doi:10.2460/ajvr.82.8.653
      PubMed
    
    3. 
    
    
  3. 
      [3]
      N Sivaranjani et al..
      J Clin Diagn Res.
      2013.
      Role of reactive oxygen species and antioxidants in atopic dermatitis.
      doi:10.7860/JCDR/2013/6635.3732
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Chiara De Luca et al..
      Int J Environ Res Public Health.
      2011.
      The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.
      doi:10.3390/ijerph8072770
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Y Jammes et al..
      J Intern Med.
      2005.
      Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise.
      doi:10.1111/j.1365-2796.2005.01452.x
      PubMed
    
    6. 
    
    
  6. 
      [6]
      N Morley et al..
      J Photochem Photobiol B.
      2003.
      N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts.
      doi:10.1016/j.jphotobiol.2003.06.004
      PubMed
    
    7. 
    
  















    

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