Zinc para Wound Healing
A Evidências Vários grandes ensaios clínicos mostram de forma consistente benefícios significativos.Well-established evidence that zinc is essential for wound healing. Zinc deficiency impairs all phases of repair. Supplementation in deficient individuals may help accelerate wound closure.
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A
Conclusão
Well-established evidence that zinc is essential for wound healing. Zinc deficiency impairs all phases of repair. Supplementation in deficient individuals may help accelerate wound closure.
Key Study Findings
Review
UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: Elite/professional cyclists nutrition review
Observational Study
Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: Dogs with intervertebral disc herniation
In Vitro
Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing.
Dose: None
vs: None
Outcome: Diabetic wound healing
Efeito: None
None
População: Diabetic wound model
Systematic Review
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Dose: None
vs: Control
Outcome: Wound healing
Efeito: None
None
População: Diabetic patients
In Vitro
Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing.
Dose: SA-Arg-Zn2+ hydrogel
vs: Other dressing materials
Outcome: Wound healing, antibacterial, antioxidant
Efeito: None
None
População: In vitro + animal wound model
Other
[Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot].
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: chronic wounds and have been linked to delayed wound healing and dehiscence
Key Statistics
18
Estudos
1500
Participantes
↑
Positive
A
Nota
Referenced Papers
Journal of colloid …
2025
8 citações
International journal of …
2025
2 citações
Metabolites
2025
Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review.
Systematic Review
Nutrition (Burbank, Los …
2024
12 citações
Carbohydrate polymers
2023
86 citações
Theranostics
2023
65 citações
Heliyon
2022
117 citações
Nutricion hospitalaria
2021
20 citações
The Cochrane database …
2020
33 citações
International journal of …
2019
265 citações
Annals of internal …
2015
110 citações
Inflammatory bowel diseases
2012
224 citações
Current opinion in …
2009
66 citações
American journal of …
2005
140 citações
Metal ions in …
2004
Zinc supplementation.
Other
Journal of the …
2000
52 citações
Nutrition and wound healing.
Review
JPEN. Journal of …
1994
72 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 8-11 mg/day (RDA)
- acneskinhealth:
- 15-30 mg/day
Limite superior: 40 mg/day (elemental zinc — higher doses may cause copper depletion)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| SA-Arg-Zn2+ hydrogel | -- | Positive | -- |
| None | -- | Positive | -- |
| 20 g | -- | Neutral | 629 |
| None | -- | Mixed | -- |
Melhor horário: With meals to reduce nausea; avoid taking with iron or calcium
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Nausea (especially on empty stomach)
- ⚠ Copper depletion with long-term high-dose use
- ⚠ Metallic taste
- ⚠ Headache
Interações Conhecidas
- ● Copper supplements (mutual absorption competition — separate by 2+ hours)
- ● Tetracycline and quinolone antibiotics (reduced antibiotic absorption)
- ● Penicillamine (reduced absorption of both)
- ● Iron supplements (competitive absorption)
Ingestão máxima tolerável: 40 mg/day (elemental zinc — higher doses may cause copper depletion)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Zinc help with Wound Healing?
Based on 18 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Wound Healing management. Our evidence grade is A (Strong Evidence).
How much Zinc should I take for Wound Healing?
Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Zinc?
Reported side effects may include Nausea (especially on empty stomach), Copper depletion with long-term high-dose use, Metallic taste, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Zinc and Wound Healing?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 18 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Wound Healing
Zinc para outras condições
References
- [1] Jialiang Pan et al.. J Colloid Interface Sci. 2025. Glucose-responsive multifunctional hydrogel incorporating GOx@ZIF-8 for NO/Zn2+-mediated antibacterial and pro-angiogenic diabetic wound healing. doi:10.1016/j.jcis.2025.138423 PubMed
- [2] Patrick B Wilson et al.. Int J Sport Nutr Exerc Metab. 2025. UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. doi:10.1123/ijsnem.2025-0144 PubMed
- [3] Anita Horvatić et al.. Metabolites. 2025. Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. doi:10.3390/metabo15060396 PubMed
- [4] Allan Carlos Soares do Espírito Santo et al.. Nutrition. 2024. Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review. doi:10.1016/j.nut.2024.112449 PubMed
- [5] Ganzhe Mao et al.. Carbohydr Polym. 2023. Preparation and evaluation of a novel alginate-arginine-zinc ion hydrogel film for skin wound healing. doi:10.1016/j.carbpol.2023.120757 PubMed
- [6] Yating Yang et al.. Theranostics. 2023. Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth. doi:10.7150/thno.84118 PubMed
- [7] Ajay Kumar et al.. Heliyon. 2022. A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.). doi:10.1016/j.heliyon.2021.e08669 PubMed
- [8] Rosa María Martínez García et al.. Nutr Hosp. 2021. [Nutrition in the prevention and healing of chronic wounds. Importance in improving the diabetic foot]. doi:10.20960/nh.03800 PubMed
- [9] Zena Eh Moore et al.. Cochrane Database Syst Rev. 2020. Nutritional interventions for treating foot ulcers in people with diabetes. doi:10.1002/14651858.CD011378.pub2 PubMed
- [10] Martina Barchitta et al.. Int J Mol Sci. 2019. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. doi:10.3390/ijms20051119 PubMed
- [11] Emanuele Cereda et al.. Ann Intern Med. 2015. A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers: a randomized trial. doi:10.7326/M14-0696 PubMed
- [12] Caroline Hwang et al.. Inflamm Bowel Dis. 2012. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. doi:10.1002/ibd.22906 PubMed
- [13] Sabine Ellinger et al.. Curr Opin Clin Nutr Metab Care. 2009. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. doi:10.1097/MCO.0b013e328331a5b5 PubMed
- [14] Renata Strumia. Am J Clin Dermatol. 2005. Dermatologic signs in patients with eating disorders. doi:10.2165/00128071-200506030-00003 PubMed
- [15] Paul W Jones et al.. Met Ions Biol Syst. 2004. The use and role of zinc and its compounds in wound healing. PubMed
- [16] C J Klein. J Am Diet Assoc. 2000. Zinc supplementation. doi:10.1016/S0002-8223(00)00331-X PubMed
- [17] J E Albina. JPEN J Parenter Enteral Nutr. 1994. Nutrition and wound healing. doi:10.1177/014860719401800417 PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.