Vitamin D 관련 건선
B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.
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B
결론
Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.
Key Study Findings
Observational Study
n=573
Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.
Dose: None
vs: None
Outcome: Vitiligo prevalence and clinical characteristics
효과: None
None
대상 집단: Saudi patients with vitiligo (573)
retrospective observational with Mendelian randomization
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Dose: None
vs: Placebo
효과: OR 1.86 (95% CI 1.19-2.92)
0.007
Review
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Dose: 14 nutritional compounds (vitamins, minerals, etc.)
vs: None
Outcome: Skin health and barrier function
효과: None
None
대상 집단: General population (skin health review)
Review
[Not Available].
Dose: None
vs: None
Outcome: body weight/composition
효과: None
None
대상 집단: Coeliac disease or merely presence of coeliac-specific antibodies
Review
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases.
Dose: None
vs: None
Outcome: hair regrowth
효과: None
None
대상 집단: None
Other
n=332984
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis.
Dose: Vitamin D (25OHD, genetically predicted)
vs: Genetic instrument comparison
Outcome: Autoimmune disease risk
효과: None
None
대상 집단: UK Biobank participants (332,984)
Key Statistics
16
연구
2200
참여자
↑
Positive
B
등급
Referenced Papers
Clinical, cosmetic and …
2024
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Other
Skin research and …
2024
Medicina (Kaunas, Lithuania)
2023
41 인용
Seminars in arthritis …
2023
17 인용
Mini reviews in …
2023
9 인용
[Not Available].
Review
Ugeskrift for laeger
2023
BMJ (Clinical research …
2022
307 인용
Dermatologic therapy
2022
42 인용
Journal of the …
2020
57 인용
American journal of …
2018
138 인용
Clinics in dermatology
2016
19 인용
Journal of the …
2014
93 인용
Off-label uses of topical vitamin D in dermatology: a systematic review.
Systematic Review
Journal of cutaneous …
2014
35 인용
Autoimmune diseases
2012
Chronic plaque psoriasis.
Review
American family physician
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 600-800 IU/day (RDA)
- skinhealth:
- 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)
상한량: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Neutral | 573 |
| None | -- | Mixed | -- |
| 14 nutritional compounds (vitamins, minerals, etc.) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| Vitamin D (25OHD, genetically predicted) | -- | Positive | 332984 |
| None | -- | Positive | -- |
| 2000 IU/day vitamin D + 1g/day omega-3 | 260 weeks | Positive | 25871 |
권장 복용 시간: With meals containing fat for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ Generally well-tolerated at recommended doses
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones (rare, at excessive doses)
알려진 상호작용
- ● Thiazide diuretics (may increase calcium levels)
- ● Corticosteroids (may reduce vitamin D absorption)
- ● Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
- ● Calcipotriene (additive vitamin D effect)
일일 최대 섭취 허용량: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Vitamin D help with 건선?
Based on 16 studies with 2,200 participants, there is moderate evidence from clinical studies that Vitamin D may support 건선 management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for 건선?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and 건선?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 2,200 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: 건선
Vitamin D 다른 건강 상태에 대한 근거
References
- [1] Mohammed Ibrahim AlJasser. Clin Cosmet Investig Dermatol. 2024. Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients. doi:10.2147/CCID.S499794 PubMed
- [2] Yuting Cao et al.. Skin Res Technol. 2024. Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study. doi:10.1111/srt.13911 PubMed
- [3] Jacek Januszewski et al.. Medicina (Kaunas). 2023. Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why. doi:10.3390/medicina60010068 PubMed
- [4] Sizheng Steven Zhao et al.. Semin Arthritis Rheum. 2023. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. doi:10.1016/j.semarthrit.2023.152238 PubMed
- [5] Yilan Zeng et al.. Mini Rev Med Chem. 2023. The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. doi:10.2174/1389557523666221124123206 PubMed
- [6] Charlotte Näslund-Koch et al.. Ugeskr Laeger. 2023. [Not Available]. PubMed
- [7] Jill Hahn et al.. BMJ. 2022. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. doi:10.1136/bmj-2021-066452 PubMed
- [8] Sofia Nogueira et al.. Dermatol Ther. 2022. Tapinarof for the treatment of psoriasis. doi:10.1111/dth.15931 PubMed
- [9] R Z Conic et al.. J Eur Acad Dermatol Venereol. 2020. Comorbidities in pediatric alopecia areata. doi:10.1111/jdv.16727 PubMed
- [10] Elio Kechichian et al.. Am J Clin Dermatol. 2018. Vitamin D and the Skin: An Update for Dermatologists. doi:10.1007/s40257-017-0323-8 PubMed
- [11] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [12] Jillian W Millsop et al.. J Am Acad Dermatol. 2014. Diet and psoriasis, part III: role of nutritional supplements. doi:10.1016/j.jaad.2014.03.016 PubMed
- [13] Heidi Wat et al.. J Cutan Med Surg. 2014. Off-label uses of topical vitamin D in dermatology: a systematic review. doi:10.2310/7750.2013.13109 PubMed
- [14] Michael P Pender. Autoimmune Dis. 2012. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. doi:10.1155/2012/189096 PubMed
- [15] Kelly M Luba et al.. Am Fam Physician. 2006. Chronic plaque psoriasis. PubMed
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.