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Vitamin D 用于 Psoriasis

B

Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.

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            B

        

        

            
结论

            
            
Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
16

        
研究数量

    

    

        
2200

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
600-800 IU/day (RDA)

                    

                    
                    

                        
skinhealth:

                        
1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)

                    

                    
                

                
                

                    上限： 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
                

                
            

            

            

            
            

                最佳服用时间： With meals containing fat for better absorption
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
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                            ⚠
                            Generally well-tolerated at recommended doses
                        
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                            Hypercalcemia at very high doses (nausea, vomiting, weakness)
                        
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                            ⚠
                            Kidney stones (rare, at excessive doses)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
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                            ●
                            Thiazide diuretics (may increase calcium levels)
                        
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                            Corticosteroids (may reduce vitamin D absorption)
                        
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                            Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
                        
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                            Calcipotriene (additive vitamin D effect)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin D help with Psoriasis?
            
        
        

            Based on 16 studies with 2,200 participants, there is moderate evidence from clinical studies that Vitamin D may support Psoriasis management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Vitamin D should I take for Psoriasis?
            
        
        

            Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin D?
            
        
        

            Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin D and Psoriasis?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 2,200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Vitamin D 用于其他健康状况

                    

                        
                        
                            Eczema (Atopic Dermatitis)
                            B

                        
                        
                        
                            Vitiligo
                            D

                        
                        
                    

                

                
            

        

        

    


    
    












    

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