Vitamin D 用于 银屑病
B 证据 至少一项随机试验支持这一结论，结果基本一致。Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'skincited.com';
const params = 'ingredient\u003Dvitamin\u002Dd\u0026condition\u003Dpsoriasis';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
B
结论
Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.
Key Study Findings
Observational Study
n=573
Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.
Dose: None
vs: None
Outcome: Vitiligo prevalence and clinical characteristics
效果: None
None
研究人群: Saudi patients with vitiligo (573)
retrospective observational with Mendelian randomization
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Dose: None
vs: Placebo
效果: OR 1.86 (95% CI 1.19-2.92)
0.007
Review
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Dose: 14 nutritional compounds (vitamins, minerals, etc.)
vs: None
Outcome: Skin health and barrier function
效果: None
None
研究人群: General population (skin health review)
Review
[Not Available].
Dose: None
vs: None
Outcome: body weight/composition
效果: None
None
研究人群: Coeliac disease or merely presence of coeliac-specific antibodies
Review
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases.
Dose: None
vs: None
Outcome: hair regrowth
效果: None
None
研究人群: None
Other
n=332984
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis.
Dose: Vitamin D (25OHD, genetically predicted)
vs: Genetic instrument comparison
Outcome: Autoimmune disease risk
效果: None
None
研究人群: UK Biobank participants (332,984)
Key Statistics
16
研究数量
2200
受试者
↑
Positive
B
等级
Referenced Papers
Clinical, cosmetic and …
2024
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Other
Skin research and …
2024
Medicina (Kaunas, Lithuania)
2023
41 次引用
Seminars in arthritis …
2023
17 次引用
Mini reviews in …
2023
9 次引用
[Not Available].
Review
Ugeskrift for laeger
2023
BMJ (Clinical research …
2022
307 次引用
Dermatologic therapy
2022
42 次引用
Journal of the …
2020
57 次引用
American journal of …
2018
138 次引用
Clinics in dermatology
2016
19 次引用
Journal of the …
2014
93 次引用
Off-label uses of topical vitamin D in dermatology: a systematic review.
Systematic Review
Journal of cutaneous …
2014
35 次引用
Autoimmune diseases
2012
Chronic plaque psoriasis.
Review
American family physician
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-800 IU/day (RDA)
- skinhealth:
- 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)
上限： 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Neutral | 573 |
| None | -- | Mixed | -- |
| 14 nutritional compounds (vitamins, minerals, etc.) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| Vitamin D (25OHD, genetically predicted) | -- | Positive | 332984 |
| None | -- | Positive | -- |
| 2000 IU/day vitamin D + 1g/day omega-3 | 260 weeks | Positive | 25871 |
最佳服用时间： With meals containing fat for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Generally well-tolerated at recommended doses
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones (rare, at excessive doses)
已知相互作用
- ● Thiazide diuretics (may increase calcium levels)
- ● Corticosteroids (may reduce vitamin D absorption)
- ● Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
- ● Calcipotriene (additive vitamin D effect)
可耐受最高摄入量： 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin D help with 银屑病?
Based on 16 studies with 2,200 participants, there is moderate evidence from clinical studies that Vitamin D may support 银屑病 management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for 银屑病?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and 银屑病?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 2,200 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 银屑病
Vitamin D 用于其他健康状况
References
- [1] Mohammed Ibrahim AlJasser. Clin Cosmet Investig Dermatol. 2024. Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients. doi:10.2147/CCID.S499794 PubMed
- [2] Yuting Cao et al.. Skin Res Technol. 2024. Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study. doi:10.1111/srt.13911 PubMed
- [3] Jacek Januszewski et al.. Medicina (Kaunas). 2023. Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why. doi:10.3390/medicina60010068 PubMed
- [4] Sizheng Steven Zhao et al.. Semin Arthritis Rheum. 2023. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. doi:10.1016/j.semarthrit.2023.152238 PubMed
- [5] Yilan Zeng et al.. Mini Rev Med Chem. 2023. The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. doi:10.2174/1389557523666221124123206 PubMed
- [6] Charlotte Näslund-Koch et al.. Ugeskr Laeger. 2023. [Not Available]. PubMed
- [7] Jill Hahn et al.. BMJ. 2022. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. doi:10.1136/bmj-2021-066452 PubMed
- [8] Sofia Nogueira et al.. Dermatol Ther. 2022. Tapinarof for the treatment of psoriasis. doi:10.1111/dth.15931 PubMed
- [9] R Z Conic et al.. J Eur Acad Dermatol Venereol. 2020. Comorbidities in pediatric alopecia areata. doi:10.1111/jdv.16727 PubMed
- [10] Elio Kechichian et al.. Am J Clin Dermatol. 2018. Vitamin D and the Skin: An Update for Dermatologists. doi:10.1007/s40257-017-0323-8 PubMed
- [11] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [12] Jillian W Millsop et al.. J Am Acad Dermatol. 2014. Diet and psoriasis, part III: role of nutritional supplements. doi:10.1016/j.jaad.2014.03.016 PubMed
- [13] Heidi Wat et al.. J Cutan Med Surg. 2014. Off-label uses of topical vitamin D in dermatology: a systematic review. doi:10.2310/7750.2013.13109 PubMed
- [14] Michael P Pender. Autoimmune Dis. 2012. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. doi:10.1155/2012/189096 PubMed
- [15] Kelly M Luba et al.. Am Fam Physician. 2006. Chronic plaque psoriasis. PubMed
FDA 免责声明: 这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。