Copper ： Wound Healing
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。Copper is essential for lysyl oxidase (collagen cross-linking) and wound healing. Most clinical evidence is for topical copper peptides rather than oral supplementation.
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D
結論
Copper is essential for lysyl oxidase (collagen cross-linking) and wound healing. Most clinical evidence is for topical copper peptides rather than oral supplementation.
Key Study Findings
Review
The role of trace elements for the function and health of the skin.
Dose: None
vs: Placebo
効果: None
None
Meta-Analysis
n=4931
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
Dose: None
vs: Placebo
効果: SMD=-0.93 (vitamin D); SMD=-0.69 (zinc); OR=2.48 (vitamin D deficiency risk)
p<0.05
Review
Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
Dose: None
vs: Placebo
効果: None
None
Systematic Review and Meta-Analysis
n=7014
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Dose: None
vs: Placebo
効果: Standardized mean differences reported for each element and disease combination (specific values not
None
case-control study
n=180
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, …
Dose: not applicable
vs: Placebo
効果: None
None
Review
Consequences of Disturbing Manganese Homeostasis.
Dose: Manganese (Mn) - exposure assessment
vs: None
Outcome: Mn toxicity mechanisms on CNS
効果: None
None
対象集団: General (manganese exposure review)
Key Statistics
3
研究数
150
参加者数
↑
Positive
D
グレード
Referenced Papers
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
Meta-Analysis
Journal of cosmetic …
2025
5 件の引用
Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.
Review
Current medicinal chemistry
2025
5 件の引用
Biomedicine & pharmacotherapy …
2025
4 件の引用
Journal of trace …
2025
4 件の引用
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Meta-Analysis
Nutrition reviews
2025
Advanced healthcare materials
2024
17 件の引用
Journal of cosmetic …
2024
7 件の引用
International journal of …
2023
120 件の引用
Bioactive materials
2023
108 件の引用
Medicine
2017
2 件の引用
Clinics in dermatology
2010
98 件の引用
The Journal of …
1993
58 件の引用
Progress in food …
1987
48 件の引用
Zeitschrift fur Hautkrankheiten
1987
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 900 mcg/day (RDA)
- skinhealth:
- 900 mcg-2 mg/day
上限量： 10 mg/day (excess competes with zinc absorption)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Negative | 4931 |
| None | -- | Positive | -- |
| None | -- | Mixed | 7014 |
| not applicable | -- | Mixed | 180 |
| Manganese (Mn) - exposure assessment | -- | Negative | -- |
| D-penicillamine and zinc gluconate | -- | Negative | 1 |
| None | -- | Mixed | 151 |
推奨摂取タイミング： With meals; avoid taking with zinc — separate by 2+ hours
Safety & Side Effects
報告されている副作用
- ⚠ Nausea and vomiting (at high doses)
- ⚠ Liver toxicity (chronic excess)
- ⚠ Zinc depletion with long-term high-dose use
既知の相互作用
- ● Zinc supplements (mutual absorption competition — separate by 2+ hours)
- ● Penicillamine (chelates copper — separate by 2+ hours)
- ● Antacids (may reduce copper absorption)
耐容上限摂取量： 10 mg/day (excess competes with zinc absorption)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Copper help with Wound Healing?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Copper may support Wound Healing management. Our evidence grade is D (Very Early Research).
How much Copper should I take for Wound Healing?
Studies have used various dosages. A commonly studied range is 900 mcg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Copper?
Reported side effects may include Nausea and vomiting (at high doses), Liver toxicity (chronic excess), Zinc depletion with long-term high-dose use. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Copper and Wound Healing?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Wound Healing
Copper 他の症状・状態について
References
- [1] Ruiying Wu et al.. J Cosmet Dermatol. 2025. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. doi:10.1111/jocd.16740 PubMed
- [2] Geir Bjørklund et al.. Curr Med Chem. 2025. Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders. doi:10.2174/0109298673348175250214054101 PubMed
- [3] Michael Kenneth Lawson. Biomed Pharmacother. 2025. Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications. doi:10.1016/j.biopha.2025.118055 PubMed
- [4] Geir Bjørklund et al.. J Trace Elem Med Biol. 2025. The role of trace elements for the function and health of the skin. doi:10.1016/j.jtemb.2025.127674 PubMed
- [5] Xinyi Shao et al.. Nutr Rev. 2025. Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis. doi:10.1093/nutrit/nuaf015 PubMed
- [6] Jie Gao et al.. Adv Healthc Mater. 2024. Traditional Scraping (Gua Sha) Combined with Copper-Curcumin Nanoparticle Oleogel for Accurate and Multi-Effective Therapy of Androgenic Alopecia. doi:10.1002/adhm.202303095 PubMed
- [7] Irem Nur Durusu Turkoglu et al.. J Cosmet Dermatol. 2024. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid … doi:10.1111/jocd.16512 PubMed
- [8] Jacek Baj et al.. Int J Mol Sci. 2023. Consequences of Disturbing Manganese Homeostasis. doi:10.3390/ijms241914959 PubMed
- [9] Zhaowenbin Zhang et al.. Bioact Mater. 2023. A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch. doi:10.1016/j.bioactmat.2022.12.007 PubMed
- [10] Ching-Fen Lee et al.. Medicine (Baltimore). 2017. Copper-associated hepatitis in a patient with chronic myeloid leukemia following hematopoietic stem cell transplantation: A case report. doi:10.1097/MD.0000000000009041 PubMed
- [11] Michael W Cashman et al.. Clin Dermatol. 2010. Nutrition and nail disease. doi:10.1016/j.clindermatol.2010.03.037 PubMed
- [12] M Tasaki et al.. J Dermatol. 1993. Analyses of serum copper and zinc levels and copper/zinc ratios in skin diseases. doi:10.1111/j.1346-8138.1993.tb03823.x PubMed
- [13] J C Wallwork. Prog Food Nutr Sci. 1987. Zinc and the central nervous system. PubMed
- [14] K Brüske et al.. Z Hautkr. 1987. [Zinc and its status in some dermatologic diseases--a statistical assessment]. PubMed
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