Niacinamide para UV Protection (Internal Photoprotection)

A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.

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Conclusión

Key Study Findings

laboratory/in vitro 26 weeks

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.

Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. vs: Placebo Efecto: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo None

review

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.

Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) vs: Placebo Efecto: None None

Review

The adverse effects of oral niacin/nicotinamide - an overview of reviews.

Dose: None vs: None Outcome: None Efecto: None None

Población: Overview of reviews on niacin/nicotinamide adverse effects

Meta-Analysis

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.

Dose: Nicotinamide (vitamin B3) vs: Placebo Outcome: AK and NMSC incidence reduction Efecto: None None

Población: High-risk NMSC patients (RCTs)

Review

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …

Dose: None vs: Placebo Efecto: None None

Other

Nicotinamide: An Update and Review of Safety & Differences from Niacin.

Dose: None vs: None Outcome: None Efecto: None None

Población: None

Key Statistics

Estudios

686

Participantes

↑

Positive

Calificación

Referenced Papers

The adverse effects of oral niacin/nicotinamide - an overview of reviews. Review

Eye (London, England) 2025 1 citas

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. Other

International journal of … 2025

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. Review

International journal for … 2025

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2023 16 citas

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. Review

Journal of the … 2021 46 citas

Nicotinamide: An Update and Review of Safety & Differences from Niacin. Other

Skin therapy letter 2020 13 citas

Final report of the safety assessment of niacinamide and niacin. Review

International journal of … 2005 22 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 14-16 mg/day NE (RDA)
skinhealth:: 500-1,500 mg/day oral nicotinamide

Límite superior: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.	26 weeks	Positive	--
Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)	--	Positive	--
None	--	Mixed	--
Nicotinamide (vitamin B3)	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Niacinamide up to 5%; Niacin up to 0.1%	--	Mixed	--

Mejor momento para tomar: With meals; can be split into 2-3 doses

Safety & Side Effects

Efectos secundarios reportados

⚠ Generally well-tolerated (no flushing unlike niacin)
⚠ Mild gastrointestinal discomfort at high doses
⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Interacciones conocidas

● Anticonvulsants (carbamazepine — may increase niacinamide levels)
● Hepatotoxic drugs (potential additive liver effect at high doses)
● Isoniazid (competes for NAD+ pathways)

Ingesta máxima tolerable: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Niacinamide help with UV Protection (Internal Photoprotection)?

Based on 5 studies with 686 participants, there is strong evidence from multiple clinical trials that Niacinamide may support UV Protection (Internal Photoprotection) management. Our evidence grade is A (Strong Evidence).

How much Niacinamide should I take for UV Protection (Internal Photoprotection)?

Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Niacinamide?

Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Niacinamide and UV Protection (Internal Photoprotection)?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 5 peer-reviewed studies with 686 total participants. The overall direction of effect is positive.

Otros ingredientes para UV Protection (Internal Photoprotection)

Nicotinamide A Omega-3 Fatty Acids B Green Tea Extract B Astaxanthin B Polypodium leucotomos B Vitamin E C

Niacinamide para otras condiciones

Acne A

Veredicto rápido

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA …

Evidence Strength92%

High confidence

Desglose de estudios

RCT (0)Meta (1)Other (4)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para UV Protection (Internal Photoprotection)

Más información

References

[1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
[2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
[3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
[4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
[5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
[6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
[7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.