Nicotinamide para UV Protection (Internal Photoprotection)
A Evidencia Múltiples ensayos clínicos de gran tamaño muestran de forma consistente beneficios significativos.At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).
Conclusión
At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).
Key Study Findings
Población: Overview of reviews on niacin/nicotinamide adverse effects
Población: High-risk NMSC patients (RCTs)
Población: None
Población: General population (cosmetic users)
Key Statistics
5
Estudios
686
Participantes
Positive
Calificación
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- generalskinbarrier:
- 500-1,500 mg/day
- skincancerchemoprevention:
- 500 mg twice daily (1,000 mg/day total)
Límite superior: Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Nicotinamide (vitamin B3) | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Niacinamide up to 5%; Niacin up to 0.1% | -- | Mixed | -- |
Mejor momento para tomar: With meals; split into 2 doses for chemoprevention
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Generally well-tolerated (no flushing)
- ⚠ Mild gastrointestinal discomfort at high doses
- ⚠ Rare hepatotoxicity at very high doses
Interacciones conocidas
- ● Anticonvulsants (carbamazepine — may increase levels)
- ● Isoniazid (competes for NAD+ pathways)
- ● Hepatotoxic drugs (potential additive liver effect at high doses)
Ingesta máxima tolerable: Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Nicotinamide help with UV Protection (Internal Photoprotection)?
How much Nicotinamide should I take for UV Protection (Internal Photoprotection)?
Are there side effects of Nicotinamide?
How strong is the evidence for Nicotinamide and UV Protection (Internal Photoprotection)?
Related Evidence
Otros ingredientes para UV Protection (Internal Photoprotection)
References
- [1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
- [2] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
- [3] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
- [4] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
- [5] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed
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