Niacinamide için UV Protection (Internal Photoprotection)

A Kanıt Birden fazla büyük klinik çalışma tutarlı biçimde önemli faydalar ortaya koymaktadır.

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.

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Key Study Findings

laboratory/in vitro 26 weeks

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.

Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. vs: Placebo Etki: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo None

review

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.

Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) vs: Placebo Etki: None None

Review

The adverse effects of oral niacin/nicotinamide - an overview of reviews.

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: Overview of reviews on niacin/nicotinamide adverse effects

Meta-Analysis

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.

Dose: Nicotinamide (vitamin B3) vs: Placebo Outcome: AK and NMSC incidence reduction Etki: None None

Popülasyon: High-risk NMSC patients (RCTs)

Review

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …

Dose: None vs: Placebo Etki: None None

Other

Nicotinamide: An Update and Review of Safety & Differences from Niacin.

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: None

Key Statistics

Çalışmalar

686

Katılımcılar

↑

Positive

Derece

Referenced Papers

The adverse effects of oral niacin/nicotinamide - an overview of reviews. Review

Eye (London, England) 2025 1 atıf

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. Other

International journal of … 2025

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. Review

International journal for … 2025

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2023 16 atıf

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. Review

Journal of the … 2021 46 atıf

Nicotinamide: An Update and Review of Safety & Differences from Niacin. Other

Skin therapy letter 2020 13 atıf

Final report of the safety assessment of niacinamide and niacin. Review

International journal of … 2005 22 atıf

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

general:: 14-16 mg/day NE (RDA)
skinhealth:: 500-1,500 mg/day oral nicotinamide

Üst sınır: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.	26 weeks	Positive	--
Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)	--	Positive	--
None	--	Mixed	--
Nicotinamide (vitamin B3)	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Niacinamide up to 5%; Niacin up to 0.1%	--	Mixed	--

En iyi alım zamanı: With meals; can be split into 2-3 doses

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Generally well-tolerated (no flushing unlike niacin)
⚠ Mild gastrointestinal discomfort at high doses
⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Bilinen Etkileşimler

● Anticonvulsants (carbamazepine — may increase niacinamide levels)
● Hepatotoxic drugs (potential additive liver effect at high doses)
● Isoniazid (competes for NAD+ pathways)

Tolere edilebilir üst alım: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Niacinamide help with UV Protection (Internal Photoprotection)?

Based on 5 studies with 686 participants, there is strong evidence from multiple clinical trials that Niacinamide may support UV Protection (Internal Photoprotection) management. Our evidence grade is A (Strong Evidence).

How much Niacinamide should I take for UV Protection (Internal Photoprotection)?

Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Niacinamide?

Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Niacinamide and UV Protection (Internal Photoprotection)?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 5 peer-reviewed studies with 686 total participants. The overall direction of effect is positive.

Şu durum için diğer içerikler: UV Protection (Internal Photoprotection)

Nicotinamide A Omega-3 Fatty Acids B Green Tea Extract B Astaxanthin B Polypodium leucotomos B Vitamin E C

Niacinamide diğer sağlık durumları için

Acne A

Hızlı Değerlendirme

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA …

Evidence Strength92%

High confidence

Çalışma Dağılımı

RCT (0)Meta (1)Other (4)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: UV Protection (Internal Photoprotection)

Daha Fazla Bilgi

References

[1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
[2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
[3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
[4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
[5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
[6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
[7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed

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