Vitamin D для Vitiligo

Q: Does Vitamin D help with Vitiligo?

Based on 4 studies with 300 participants, there is preliminary evidence that needs more research that Vitamin D may support Vitiligo management. Our evidence grade is D (Very Early Research).

Q: How much Vitamin D should I take for Vitiligo?

Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Vitamin D?

Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Vitamin D and Vitiligo?

We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

D Исследования Существуют только предварительные исследования (лабораторные исследования, описания случаев).

Research suggests vitamin D deficiency is common in vitiligo patients. Supplementation may support melanocyte function, but clinical evidence for repigmentation is limited.

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Итог

Research suggests vitamin D deficiency is common in vitiligo patients. Supplementation may support melanocyte function, but clinical evidence for repigmentation is limited.

Key Study Findings

retrospective observational with Mendelian randomization

Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.

Dose: None или: Placebo Эффект: OR 1.86 (95% CI 1.19-2.92) 0.007

Observational Study n=573

Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.

Dose: None или: None Outcome: Vitiligo prevalence and clinical characteristics Эффект: None None

Популяция: Saudi patients with vitiligo (573)

Meta-Analysis n=680823

Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis.

Dose: None или: Placebo Эффект: Vitamin D deficiency OR 10.13 (95% CI 4.24-24.20) None

Case-control n=90

Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata …

Dose: None или: Placebo Эффект: None p=0.001 (BDNF and vitamin D vs

Observational Study

Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study.

Dose: 36% или: None Outcome: hair regrowth Эффект: None p < 0.05

Популяция: Aa referred to our hospitals between 2018 and 2021

Other n=38 36 weeks

Paediatric lichen sclerosus et atrophicus: A retrospective analysis of 38 paediatric patients.

Dose: 92.1% или: None Outcome: None Эффект: None None

Популяция: lsa by a paediatric dermatologist

Key Statistics

Исследования

300

Участники

↑

Positive

Оценка

Referenced Papers

Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study. Other

Skin research and … 2024

Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients. Other

Clinical, cosmetic and … 2024

Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis. Meta-Analysis

American journal of … 2023 41 цитирований

Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study. Other

Health science reports 2023 3 цитирований

Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … Other

Journal of cosmetic … 2023 3 цитирований

Paediatric lichen sclerosus et atrophicus: A retrospective analysis of 38 paediatric patients. Other

International journal of … 2021 14 цитирований

Comorbidities in pediatric alopecia areata. Other

Journal of the … 2020 57 цитирований

Vitamin D and the Skin: An Update for Dermatologists. Review

American journal of … 2018 138 цитирований

The role of serum vitamin D levels in vitiligo. Other

Postepy dermatologii i … 2016 59 цитирований

Vitamin D deficiency in alopecia areata. Other

The British journal … 2014 74 цитирований

Off-label uses of topical vitamin D in dermatology: a systematic review. Systematic Review

Journal of cutaneous … 2014 35 цитирований

Pediatric vitiligo. Review

Pediatric clinics of … 2014 25 цитирований

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. Other

Autoimmune diseases 2012

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 600-800 IU/day (RDA)
skinhealth:: 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)

Верхний предел: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Mixed	--
None	--	Neutral	573
None	--	Positive	680823
None	--	Negative	90
36%	--	Mixed	--
92.1%	36 weeks	Positive	38
None	--	Positive	8314220
None	--	Negative	--

Лучшее время приёма: With meals containing fat for better absorption

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Generally well-tolerated at recommended doses
⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
⚠ Kidney stones (rare, at excessive doses)

Известные взаимодействия

● Thiazide diuretics (may increase calcium levels)
● Corticosteroids (may reduce vitamin D absorption)
● Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
● Calcipotriene (additive vitamin D effect)

Допустимый верхний уровень потребления: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Vitamin D help with Vitiligo?

Based on 4 studies with 300 participants, there is preliminary evidence that needs more research that Vitamin D may support Vitiligo management. Our evidence grade is D (Very Early Research).

How much Vitamin D should I take for Vitiligo?

Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Vitiligo?

We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Vitamin D для других состояний

Psoriasis B Eczema (Atopic Dermatitis) B

Краткий вывод

Research suggests vitamin D deficiency is common in vitiligo patients. Supplementation may support melanocyte function, but clinical evidence for repigmentation is limited.

Evidence Strength30%

Low confidence

Разбор исследований

RCT (0)Meta (1)Other (3)

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References

[1] Yuting Cao et al.. Skin Res Technol. 2024. Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study. doi:10.1111/srt.13911 PubMed
[2] Mohammed Ibrahim AlJasser. Clin Cosmet Investig Dermatol. 2024. Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients. doi:10.2147/CCID.S499794 PubMed
[3] Sophia Ly et al.. Am J Clin Dermatol. 2023. Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis. doi:10.1007/s40257-023-00805-4 PubMed
[4] Elham Hamidpour et al.. Health Sci Rep. 2023. Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study. doi:10.1002/hsr2.1444 PubMed
[5] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
[6] Basak Yalici-Armagan et al.. Int J Clin Pract. 2021. Paediatric lichen sclerosus et atrophicus: A retrospective analysis of 38 paediatric patients. doi:10.1111/ijcp.14661 PubMed
[7] R Z Conic et al.. J Eur Acad Dermatol Venereol. 2020. Comorbidities in pediatric alopecia areata. doi:10.1111/jdv.16727 PubMed
[8] Elio Kechichian et al.. Am J Clin Dermatol. 2018. Vitamin D and the Skin: An Update for Dermatologists. doi:10.1007/s40257-017-0323-8 PubMed
[9] Ebru Karagün et al.. Postepy Dermatol Alergol. 2016. The role of serum vitamin D levels in vitiligo. doi:10.5114/pdia.2016.59507 PubMed
[10] A Aksu Cerman et al.. Br J Dermatol. 2014. Vitamin D deficiency in alopecia areata. doi:10.1111/bjd.12980 PubMed
[11] Heidi Wat et al.. J Cutan Med Surg. 2014. Off-label uses of topical vitamin D in dermatology: a systematic review. doi:10.2310/7750.2013.13109 PubMed
[12] Nanette B Silverberg. Pediatr Clin North Am. 2014. Pediatric vitiligo. doi:10.1016/j.pcl.2013.11.008 PubMed
[13] Michael P Pender. Autoimmune Dis. 2012. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. doi:10.1155/2012/189096 PubMed

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Vitamin D для Vitiligo

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Итог

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Часто используемые дозировки

Дозировки, изученные в исследованиях

Safety & Side Effects

Зарегистрированные побочные эффекты

Известные взаимодействия

Frequently Asked Questions

Related Evidence

Vitamin D для других состояний

References