N-Acetyl Cysteine ： Hyperpigmentation
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。NAC effectively raises intracellular glutathione levels. A controlled trial found NAC (1,200 mg/day) reduced melanin index, potentially through enhanced glutathione-mediated melanin pathway modulation.
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C
結論
NAC effectively raises intracellular glutathione levels. A controlled trial found NAC (1,200 mg/day) reduced melanin index, potentially through enhanced glutathione-mediated melanin pathway modulation.
Key Study Findings
Review
Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of nanocatalytic antioxidation in diseases
Review
Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
In Vitro
Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …
Dose: None
vs: GK15 induction without NAC
Outcome: hPGCLC induction efficiency
効果: None
None
対象集団: Human iPSCs (in vitro)
Other
Milk Fat Globules: 2024 Updates.
Dose: None
vs: None
Outcome: Inflammatory markers
効果: None
None
対象集団: None
narrative review
New treatment options for the management of restless leg syndrome.
Dose: rotigotine: various doses; gabapentin enacarbil: 600 mg/day (approved dose)
vs: Placebo
効果: None
None
In Vitro
Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent.
Dose: ACE inhibitor or spironolactone + salt diet
vs: Vehicle-treated SHRsp
Outcome: Renal protection and blood pressure
効果: Renal protection was blood-pressure dependent
None
対象集団: Salt-supplemented stroke-prone SHR rats
Key Statistics
3
研究数
150
参加者数
↑
Positive
C
グレード
Referenced Papers
Phytomedicine : international …
2025
8 件の引用
Accounts of chemical …
2025
2 件の引用
Journal of biomedical …
2025
Newborn (Clarksville, Md.)
2024
9 件の引用
Scientific reports
2022
28 件の引用
Pharmaceuticals (Basel, Switzerland)
2022
8 件の引用
The Journal of …
2014
7 件の引用
Recent patents on …
2012
Hypertension (Dallas, Tex. …
2003
116 件の引用
Journal of photochemistry …
2003
71 件の引用
Arzneimittel-Forschung
1985
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 600-1,200 mg/day
- skinhealth:
- 600-1,800 mg/day
上限量： Generally well-tolerated up to 2,400 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| rotigotine: various doses; gabapentin enacarbil: 600 mg/day (approved dose) | -- | Positive | -- |
| ACE inhibitor or spironolactone + salt diet | -- | Positive | -- |
| N-acetyl-L-cysteine (NAC) | -- | Positive | -- |
| 3 ml | -- | Neutral | -- |
推奨摂取タイミング： On an empty stomach for better absorption; or with meals if GI sensitivity
Safety & Side Effects
報告されている副作用
- ⚠ Nausea and vomiting
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur smell
- ⚠ Rare: bronchospasm (in asthmatics)
既知の相互作用
- ● Nitroglycerin (may enhance vasodilatory effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (may have mild antiplatelet effects)
耐容上限摂取量： Generally well-tolerated up to 2,400 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does N-Acetyl Cysteine help with Hyperpigmentation?
Based on 3 studies with 150 participants, there is limited but promising evidence that N-Acetyl Cysteine may support Hyperpigmentation management. Our evidence grade is C (Some Evidence).
How much N-Acetyl Cysteine should I take for Hyperpigmentation?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine?
Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur smell, Rare: bronchospasm (in asthmatics). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine and Hyperpigmentation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Hyperpigmentation
References
- [1] Yun-Fei Zhu et al.. Phytomedicine. 2025. Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants. doi:10.1016/j.phymed.2025.157052 PubMed
- [2] Bowen Yang et al.. Acc Chem Res. 2025. Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. doi:10.1021/acs.accounts.5c00408 PubMed
- [3] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
- [4] Akhil Maheshwari et al.. Newborn (Clarksville). 2024. Milk Fat Globules: 2024 Updates. doi:10.5005/jp-journals-11002-0085 PubMed
- [5] Vanuchawan Wisuitiprot et al.. Sci Rep. 2022. Effects of Acanthus ebracteatus Vahl. extract and verbascoside on human dermal papilla and murine macrophage. doi:10.1038/s41598-022-04966-w PubMed
- [6] Laila Susanti et al.. Pharmaceuticals (Basel). 2022. Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In … doi:10.3390/ph15121557 PubMed
- [7] Beatriz Elizabeth Carmona Toro. J Neurosci Nurs. 2014. New treatment options for the management of restless leg syndrome. doi:10.1097/JNN.0000000000000068 PubMed
- [8] Alfredo Rossi et al.. Recent Pat Inflamm Allergy Drug Discov. 2012. Minoxidil use in dermatology, side effects and recent patents. doi:10.2174/187221312800166859 PubMed
- [9] Karen A Griffin et al.. Hypertension. 2003. Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent. doi:10.1161/01.hyp.0000049881.25304.73 PubMed
- [10] N Morley et al.. J Photochem Photobiol B. 2003. N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. doi:10.1016/j.jphotobiol.2003.06.004 PubMed
- [11] W Losert et al.. Arzneimittelforschung. 1985. Progestogens with antimineralocorticoid activity. PubMed
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