N-Acetyl Cysteine untuk Hyperpigmentation

C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.

NAC effectively raises intracellular glutathione levels. A controlled trial found NAC (1,200 mg/day) reduced melanin index, potentially through enhanced glutathione-mediated melanin pathway modulation.

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Kesimpulan

Key Study Findings

Review

Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Review of nanocatalytic antioxidation in diseases

Review

Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants.

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs: GK15 induction without NAC Outcome: hPGCLC induction efficiency Efek: None None

Populasi: Human iPSCs (in vitro)

Other

Milk Fat Globules: 2024 Updates.

Dose: None vs: None Outcome: Inflammatory markers Efek: None None

Populasi: None

narrative review

New treatment options for the management of restless leg syndrome.

Dose: rotigotine: various doses; gabapentin enacarbil: 600 mg/day (approved dose) vs: Placebo Efek: None None

In Vitro

Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent.

Dose: ACE inhibitor or spironolactone + salt diet vs: Vehicle-treated SHRsp Outcome: Renal protection and blood pressure Efek: Renal protection was blood-pressure dependent None

Populasi: Salt-supplemented stroke-prone SHR rats

Key Statistics

Studi

150

Peserta

↑

Positive

Peringkat

Referenced Papers

Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants. Review

Phytomedicine : international … 2025 8 sitasi

Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. Review

Accounts of chemical … 2025 2 sitasi

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Milk Fat Globules: 2024 Updates. Other

Newborn (Clarksville, Md.) 2024 9 sitasi

Effects of Acanthus ebracteatus Vahl. extract and verbascoside on human dermal papilla and murine macrophage. Other

Scientific reports 2022 28 sitasi

Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In … Other

Pharmaceuticals (Basel, Switzerland) 2022 8 sitasi

New treatment options for the management of restless leg syndrome. Review

The Journal of … 2014 7 sitasi

Minoxidil use in dermatology, side effects and recent patents. Review

Recent patents on … 2012

Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent. Other

Hypertension (Dallas, Tex. … 2003 116 sitasi

N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. Other

Journal of photochemistry … 2003 71 sitasi

Progestogens with antimineralocorticoid activity. Other

Arzneimittel-Forschung 1985

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 600-1,200 mg/day
skinhealth:: 600-1,800 mg/day

Batas atas: Generally well-tolerated up to 2,400 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
rotigotine: various doses; gabapentin enacarbil: 600 mg/day (approved dose)	--	Positive	--
ACE inhibitor or spironolactone + salt diet	--	Positive	--
N-acetyl-L-cysteine (NAC)	--	Positive	--
3 ml	--	Neutral	--

Waktu terbaik diminum: On an empty stomach for better absorption; or with meals if GI sensitivity

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Nausea and vomiting
⚠ Diarrhea
⚠ Unpleasant sulfur smell
⚠ Rare: bronchospasm (in asthmatics)

Interaksi yang Diketahui

● Nitroglycerin (may enhance vasodilatory effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (may have mild antiplatelet effects)

Asupan atas yang dapat ditoleransi: Generally well-tolerated up to 2,400 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does N-Acetyl Cysteine help with Hyperpigmentation?

Based on 3 studies with 150 participants, there is limited but promising evidence that N-Acetyl Cysteine may support Hyperpigmentation management. Our evidence grade is C (Some Evidence).

How much N-Acetyl Cysteine should I take for Hyperpigmentation?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine?

Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur smell, Rare: bronchospasm (in asthmatics). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine and Hyperpigmentation?

We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.

Bahan lain untuk Hyperpigmentation

Glutathione C Pine Bark Extract (Pycnogenol) C Polypodium leucotomos C Grape Seed Extract C

Kesimpulan Singkat

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (0)Meta (0)Other (3)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Hyperpigmentation

Pelajari Lebih Lanjut

References

[1] Yun-Fei Zhu et al.. Phytomedicine. 2025. Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants. doi:10.1016/j.phymed.2025.157052 PubMed
[2] Bowen Yang et al.. Acc Chem Res. 2025. Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. doi:10.1021/acs.accounts.5c00408 PubMed
[3] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
[4] Akhil Maheshwari et al.. Newborn (Clarksville). 2024. Milk Fat Globules: 2024 Updates. doi:10.5005/jp-journals-11002-0085 PubMed
[5] Vanuchawan Wisuitiprot et al.. Sci Rep. 2022. Effects of Acanthus ebracteatus Vahl. extract and verbascoside on human dermal papilla and murine macrophage. doi:10.1038/s41598-022-04966-w PubMed
[6] Laila Susanti et al.. Pharmaceuticals (Basel). 2022. Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In … doi:10.3390/ph15121557 PubMed
[7] Beatriz Elizabeth Carmona Toro. J Neurosci Nurs. 2014. New treatment options for the management of restless leg syndrome. doi:10.1097/JNN.0000000000000068 PubMed
[8] Alfredo Rossi et al.. Recent Pat Inflamm Allergy Drug Discov. 2012. Minoxidil use in dermatology, side effects and recent patents. doi:10.2174/187221312800166859 PubMed
[9] Karen A Griffin et al.. Hypertension. 2003. Renoprotection by ACE inhibition or aldosterone blockade is blood pressure-dependent. doi:10.1161/01.hyp.0000049881.25304.73 PubMed
[10] N Morley et al.. J Photochem Photobiol B. 2003. N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. doi:10.1016/j.jphotobiol.2003.06.004 PubMed
[11] W Losert et al.. Arzneimittelforschung. 1985. Progestogens with antimineralocorticoid activity. PubMed

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