Niacinamide per UV Protection (Internal Photoprotection)

A Evidenze Più grandi trial clinici mostrano in modo costante benefici significativi.

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA repair via NAD+ replenishment.

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In sintesi

Key Study Findings

laboratory/in vitro 26 weeks

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line.

Dose: F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0. vs: Placebo Effetto: F1 and F3 stable for 180 days; F2 stable for 14 days; F4 and F5 stable for 150 days; F6/F7 stable fo None

review

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.

Dose: Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor) vs: Placebo Effetto: None None

Review

The adverse effects of oral niacin/nicotinamide - an overview of reviews.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Overview of reviews on niacin/nicotinamide adverse effects

Meta-Analysis

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.

Dose: Nicotinamide (vitamin B3) vs: Placebo Outcome: AK and NMSC incidence reduction Effetto: None None

Popolazione: High-risk NMSC patients (RCTs)

Review

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …

Dose: None vs: Placebo Effetto: None None

Other

Nicotinamide: An Update and Review of Safety & Differences from Niacin.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Key Statistics

Studi

686

Partecipanti

↑

Positive

Grado

Referenced Papers

The adverse effects of oral niacin/nicotinamide - an overview of reviews. Review

Eye (London, England) 2025 1 citazioni

Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. Other

International journal of … 2025

Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. Review

International journal for … 2025

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2023 16 citazioni

Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. Review

Journal of the … 2021 46 citazioni

Nicotinamide: An Update and Review of Safety & Differences from Niacin. Other

Skin therapy letter 2020 13 citazioni

Final report of the safety assessment of niacinamide and niacin. Review

International journal of … 2005 22 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 14-16 mg/day NE (RDA)
skinhealth:: 500-1,500 mg/day oral nicotinamide

Limite massimo: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
F1: biotin 0.5%, caffeine 2.0%, niacinamide 2.0%; F2: finasteride 0.1%, minoxidil 1.0%, tretinoin 0.	26 weeks	Positive	--
Vitamin B complex (various B vitamins including niacinamide/NAD+ precursor)	--	Positive	--
None	--	Mixed	--
Nicotinamide (vitamin B3)	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Niacinamide up to 5%; Niacin up to 0.1%	--	Mixed	--

Momento migliore per l'assunzione: With meals; can be split into 2-3 doses

Safety & Side Effects

Effetti collaterali segnalati

⚠ Generally well-tolerated (no flushing unlike niacin)
⚠ Mild gastrointestinal discomfort at high doses
⚠ Rare hepatotoxicity at very high doses (> 3,000 mg/day)

Interazioni note

● Anticonvulsants (carbamazepine — may increase niacinamide levels)
● Hepatotoxic drugs (potential additive liver effect at high doses)
● Isoniazid (competes for NAD+ pathways)

Livello di assunzione massimo tollerabile: 35 mg/day for niacin (flushing form); nicotinamide well-tolerated up to 3,000 mg/day

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Niacinamide help with UV Protection (Internal Photoprotection)?

Based on 5 studies with 686 participants, there is strong evidence from multiple clinical trials that Niacinamide may support UV Protection (Internal Photoprotection) management. Our evidence grade is A (Strong Evidence).

How much Niacinamide should I take for UV Protection (Internal Photoprotection)?

Studies have used various dosages. A commonly studied range is 14-16 mg/day NE (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Niacinamide?

Reported side effects may include Generally well-tolerated (no flushing unlike niacin), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses (> 3,000 mg/day). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Niacinamide and UV Protection (Internal Photoprotection)?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 5 peer-reviewed studies with 686 total participants. The overall direction of effect is positive.

Altri ingredienti per UV Protection (Internal Photoprotection)

Nicotinamide A Omega-3 Fatty Acids B Green Tea Extract B Astaxanthin B Polypodium leucotomos B Vitamin E C

Niacinamide per altre condizioni

Acne A

Verdetto rapido

The ONTRAC trial (NEJM 2015) found oral nicotinamide 500 mg twice daily reduced new nonmelanoma skin cancers by 23% and actinic keratoses by 11% in high-risk individuals, supporting cellular DNA …

Evidence Strength92%

High confidence

Analisi degli studi

RCT (0)Meta (1)Other (4)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per UV Protection (Internal Photoprotection)

Approfondimenti

References

[1] Su Ling Young et al.. Eye (Lond). 2025. The adverse effects of oral niacin/nicotinamide - an overview of reviews. doi:10.1038/s41433-025-04027-2 PubMed
[2] Carolina Schettino Kegele et al.. Int J Pharm Compd. 2025. Personalized Compounded Hair Loss Treatments: A Compatibility Assessment of the TrichoConcept™ Vehicle Line. PubMed
[3] Feiya Du et al.. Int J Vitam Nutr Res. 2025. Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits. doi:10.31083/IJVNR39087 PubMed
[4] Giulio Tosti et al.. Nutrients. 2023. The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis. doi:10.3390/nu16010100 PubMed
[5] Katherine G Thompson et al.. J Am Acad Dermatol. 2021. Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. doi:10.1016/j.jaad.2020.04.123 PubMed
[6] Reed Huber et al.. Skin Therapy Lett. 2020. Nicotinamide: An Update and Review of Safety & Differences from Niacin. PubMed
[7] Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2005. Final report of the safety assessment of niacinamide and niacin. doi:10.1080/10915810500434183 PubMed

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.