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Vitamin D for Psoriasis

B

Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.

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The Bottom Line

            
            
Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
16

        
Studies

    

    

        
2200

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
600-800 IU/day (RDA)

                    

                    
                    

                        
skinhealth:

                        
1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)

                    

                    
                

                
                

                    Upper limit: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
                

                
            

            

            

            
            

                Best taken: With meals containing fat for better absorption
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Generally well-tolerated at recommended doses
                        
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                            ⚠
                            Hypercalcemia at very high doses (nausea, vomiting, weakness)
                        
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                            ⚠
                            Kidney stones (rare, at excessive doses)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
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                            ●
                            Thiazide diuretics (may increase calcium levels)
                        
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                            Corticosteroids (may reduce vitamin D absorption)
                        
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                            Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
                        
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                            Calcipotriene (additive vitamin D effect)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin D help with Psoriasis?
            
        
        

            Based on 16 studies with 2,200 participants, there is moderate evidence from clinical studies that Vitamin D may support Psoriasis management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Vitamin D should I take for Psoriasis?
            
        
        

            Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin D?
            
        
        

            Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin D and Psoriasis?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 2,200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Other ingredients for Psoriasis

                    

                        
                        
                            Turmeric (Curcumin)
                            C

                        
                        
                        
                            Omega-3 Fatty Acids
                            D

                        
                        
                    

                

                

                
                

                    
Vitamin D for other conditions

                    

                        
                        
                            Eczema (Atopic Dermatitis)
                            B

                        
                        
                        
                            Vitiligo
                            D

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.