Vitamin D के लिए Psoriasis
B संबंधित साक्ष्य कम से कम एक यादृच्छिक परीक्षण इसका समर्थन करता है, जिसके परिणाम अधिकतर सुसंगत हैं।Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.
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B
निष्कर्ष
Vitamin D deficiency is significantly associated with increased psoriasis severity. Research suggests supplementation (1,000-4,000 IU/day) may support skin immune regulation via vitamin D receptor-mediated keratinocyte differentiation.
Key Study Findings
Observational Study
n=573
Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.
Dose: None
बनाम: None
Outcome: Vitiligo prevalence and clinical characteristics
प्रभाव: None
None
जनसंख्या: Saudi patients with vitiligo (573)
retrospective observational with Mendelian randomization
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Dose: None
बनाम: Placebo
प्रभाव: OR 1.86 (95% CI 1.19-2.92)
0.007
Review
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Dose: 14 nutritional compounds (vitamins, minerals, etc.)
बनाम: None
Outcome: Skin health and barrier function
प्रभाव: None
None
जनसंख्या: General population (skin health review)
Review
[Not Available].
Dose: None
बनाम: None
Outcome: body weight/composition
प्रभाव: None
None
जनसंख्या: Coeliac disease or merely presence of coeliac-specific antibodies
Review
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases.
Dose: None
बनाम: None
Outcome: hair regrowth
प्रभाव: None
None
जनसंख्या: None
Other
n=332984
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis.
Dose: Vitamin D (25OHD, genetically predicted)
बनाम: Genetic instrument comparison
Outcome: Autoimmune disease risk
प्रभाव: None
None
जनसंख्या: UK Biobank participants (332,984)
Key Statistics
16
अध्ययन
2200
प्रतिभागी
↑
Positive
B
ग्रेड
Referenced Papers
Clinical, cosmetic and …
2024
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Other
Skin research and …
2024
Medicina (Kaunas, Lithuania)
2023
41 उद्धरण
Seminars in arthritis …
2023
17 उद्धरण
Mini reviews in …
2023
9 उद्धरण
[Not Available].
Review
Ugeskrift for laeger
2023
BMJ (Clinical research …
2022
307 उद्धरण
Dermatologic therapy
2022
42 उद्धरण
Journal of the …
2020
57 उद्धरण
American journal of …
2018
138 उद्धरण
Clinics in dermatology
2016
19 उद्धरण
Journal of the …
2014
93 उद्धरण
Off-label uses of topical vitamin D in dermatology: a systematic review.
Systematic Review
Journal of cutaneous …
2014
35 उद्धरण
Autoimmune diseases
2012
Chronic plaque psoriasis.
Review
American family physician
2006
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 600-800 IU/day (RDA)
- skinhealth:
- 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)
अधिकतम सीमा: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Neutral | 573 |
| None | -- | Mixed | -- |
| 14 nutritional compounds (vitamins, minerals, etc.) | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| Vitamin D (25OHD, genetically predicted) | -- | Positive | 332984 |
| None | -- | Positive | -- |
| 2000 IU/day vitamin D + 1g/day omega-3 | 260 weeks | Positive | 25871 |
सेवन का सर्वोत्तम समय: With meals containing fat for better absorption
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Generally well-tolerated at recommended doses
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones (rare, at excessive doses)
ज्ञात अंतःक्रियाएँ
- ● Thiazide diuretics (may increase calcium levels)
- ● Corticosteroids (may reduce vitamin D absorption)
- ● Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
- ● Calcipotriene (additive vitamin D effect)
सहनीय अधिकतम सेवन: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Vitamin D help with Psoriasis?
Based on 16 studies with 2,200 participants, there is moderate evidence from clinical studies that Vitamin D may support Psoriasis management. Our evidence grade is B (Good Evidence).
How much Vitamin D should I take for Psoriasis?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Psoriasis?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 2,200 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Psoriasis
Vitamin D अन्य स्वास्थ्य स्थितियों के लिए
References
- [1] Mohammed Ibrahim AlJasser. Clin Cosmet Investig Dermatol. 2024. Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients. doi:10.2147/CCID.S499794 PubMed
- [2] Yuting Cao et al.. Skin Res Technol. 2024. Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study. doi:10.1111/srt.13911 PubMed
- [3] Jacek Januszewski et al.. Medicina (Kaunas). 2023. Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why. doi:10.3390/medicina60010068 PubMed
- [4] Sizheng Steven Zhao et al.. Semin Arthritis Rheum. 2023. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. doi:10.1016/j.semarthrit.2023.152238 PubMed
- [5] Yilan Zeng et al.. Mini Rev Med Chem. 2023. The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. doi:10.2174/1389557523666221124123206 PubMed
- [6] Charlotte Näslund-Koch et al.. Ugeskr Laeger. 2023. [Not Available]. PubMed
- [7] Jill Hahn et al.. BMJ. 2022. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. doi:10.1136/bmj-2021-066452 PubMed
- [8] Sofia Nogueira et al.. Dermatol Ther. 2022. Tapinarof for the treatment of psoriasis. doi:10.1111/dth.15931 PubMed
- [9] R Z Conic et al.. J Eur Acad Dermatol Venereol. 2020. Comorbidities in pediatric alopecia areata. doi:10.1111/jdv.16727 PubMed
- [10] Elio Kechichian et al.. Am J Clin Dermatol. 2018. Vitamin D and the Skin: An Update for Dermatologists. doi:10.1007/s40257-017-0323-8 PubMed
- [11] Meagen McCusker et al.. Clin Dermatol. 2016. Nutrition and skin: Kids are not just little people. doi:10.1016/j.clindermatol.2016.07.004 PubMed
- [12] Jillian W Millsop et al.. J Am Acad Dermatol. 2014. Diet and psoriasis, part III: role of nutritional supplements. doi:10.1016/j.jaad.2014.03.016 PubMed
- [13] Heidi Wat et al.. J Cutan Med Surg. 2014. Off-label uses of topical vitamin D in dermatology: a systematic review. doi:10.2310/7750.2013.13109 PubMed
- [14] Michael P Pender. Autoimmune Dis. 2012. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. doi:10.1155/2012/189096 PubMed
- [15] Kelly M Luba et al.. Am Fam Physician. 2006. Chronic plaque psoriasis. PubMed
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।