Skip to main content
SkinCited

Polypodium leucotomos
Polypodium leucotomos

specialty

别名: PLE, Fernblock, Heliocare, Calaguala, Anapsos

<\/script>\n
`; }, get iframeSnippet() { const domain = 'skincited.com'; const params = 'ingredient\u003Dpolypodium\u002Dleucotomos'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    


    
    

      Widget powered by
      .
      Free, no account required.
    

  




    






    
    

        
        
        

            

  
About





            

                
Polypodium leucotomos is a tropical fern extract that reduces UV-induced oxidative stress and DNA damage. A systematic review of 5 RCTs found oral PLE significantly increased the minimal erythema dose (MED) by 1.5-2.8x. The American Academy of Dermatology has acknowledged PLE as a potential adjunct to topical sunscreen.

            

        

        

        
        
        

            

  
How It Works





            

                
Tropical fern extract rich in phenolic compounds that reduce UV-induced oxidative stress; inhibits MMP-1 expression; suppresses UV-mediated COX-2 and AP-1 activation; reduces UV-induced DNA damage (cyclobutane pyrimidine dimers); may modulate Langerhans cell depletion from UV exposure.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        UV Protection (Internal Photoprotection)
                                    
                                
                                
                                    B

                                
                                
                                    5
                                
                                
                                    250
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Hyperpigmentation
                                    
                                
                                
                                    C

                                
                                
                                    3
                                
                                
                                    150
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
  • 
                    
                    Generally well-tolerated
                
    • 
                
                
  • 
                    
                    Mild gastrointestinal discomfort (rare)
                
    • 
                
                
  • 
                    
                    Pruritus (rare)
                
    • 
                
            

        

        

        
        
        

            

  
Drug & Supplement Interactions





            
    
                
                
  • 
                    
                    Immunosuppressants (may modulate immune function)
                
    • 
                
                
  • 
                    
                    Photosensitizing medications (may modulate UV response)
                
    • 
                
            

            

                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Pine Bark Extract (Pycnogenol)
                    
                
                
                
                    Nicotinamide
                    
                
                
                
                    MSM
                    
                
                
            

        

        
    


    
    












    

        FDA 免责声明:
        这些声明未经美国食品药品监督管理局（FDA）评估。本网站上的产品和信息无意用于诊断、治疗、治愈或预防任何疾病。所展示的证据等级基于我们对已发表的同行评审研究的分析，不构成医疗建议。在开始任何补充剂方案之前，请务必咨询您的医疗保健提供者。