Hyaluronic Acid 用于 皮肤干燥
B 证据 至少一项随机试验支持这一结论，结果基本一致。Multiple RCTs found oral hyaluronic acid (120-240 mg/day) significantly improved skin moisture and reduced transepidermal water loss (TEWL) over 4-8 weeks compared to placebo.
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B
结论
Multiple RCTs found oral hyaluronic acid (120-240 mg/day) significantly improved skin moisture and reduced transepidermal water loss (TEWL) over 4-8 weeks compared to placebo.
Key Study Findings
animal study
A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and …
Dose: three-layered bioactive skin substitute (BT Skin) containing collagen type I, agarose, dermatan sulf
vs: Placebo
效果: None
None
Other
6 weeks
Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia.
Dose: None
vs: Intradermal injection hydrogel in mouse model
Outcome: Anagen induction in mouse model
效果: None
None
研究人群: Mouse model of hair loss
Other
Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia.
Dose: None
vs: Minoxidil (once/day x20) vs PL-MN (once/3 days x5)
Outcome: Hair follicle anagen induction in mouse model
效果: None
None
研究人群: Mouse model of alopecia
In Vitro
Engineered Microalgal Extracellular Vesicles for Enhancing Mitochondrial Homeostasis in Radiodermatitis Prevention.
Dose: None
vs: None
Outcome: Protection against radiation-induced cellular damage
效果: None
None
研究人群: In vitro/in vivo radiodermatitis model
Other
Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration.
Dose: None
vs: In vitro DPC model and in vivo mouse model
Outcome: DHT inhibition, ROS elimination, hair growth
效果: None
None
研究人群: Dermal papilla cells and mouse hair growth model
Case report
n=3
Cosmetic filler-induced hair loss: case series and literature review.
Dose: 5% minoxidil topical
vs: Placebo
效果: None
None
Key Statistics
10
研究数量
620
受试者
↑
Positive
B
等级
Referenced Papers
Materials today. Bio
2025
10 次引用
ACS nano
2025
6 次引用
Drug delivery and …
2025
3 次引用
International journal of …
2025
2 次引用
Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia.
Other
ACS biomaterials science …
2025
2 次引用
Regenerative biomaterials
2025
Regenerative biomaterials
2024
18 次引用
The Journal of …
2024
2 次引用
Platelet-Rich Plasma and Genital Rejuvenation.
Case Report
Skinmed
2019
7 次引用
Alternative medicine review …
2003
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 120-240 mg/day
- skinhydration:
- 120-200 mg/day
上限： Not established; well-tolerated up to 200 mg/day in trials lasting 12 months
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| three-layered bioactive skin substitute (BT Skin) containing collagen type I, agarose, dermatan sulf | -- | Positive | -- |
| None | 6 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 5% minoxidil topical | -- | Positive | 3 |
| None | -- | Positive | -- |
| Arginine, glutamine, vitamin C, zinc | -- | Positive | -- |
最佳服用时间： With meals for better absorption
Safety & Side Effects
已报告的副作用
- ⚠ Generally well-tolerated
- ⚠ Rare mild gastrointestinal discomfort
已知相互作用
- ● No significant drug interactions documented
可耐受最高摄入量： Not established; well-tolerated up to 200 mg/day in trials lasting 12 months
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Hyaluronic Acid help with 皮肤干燥?
Based on 10 studies with 620 participants, there is moderate evidence from clinical studies that Hyaluronic Acid may support 皮肤干燥 management. Our evidence grade is B (Good Evidence).
How much Hyaluronic Acid should I take for 皮肤干燥?
Studies have used various dosages. A commonly studied range is 120-240 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Hyaluronic Acid?
Reported side effects may include Generally well-tolerated, Rare mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Hyaluronic Acid and 皮肤干燥?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 620 total participants. The overall direction of effect is positive.
Related Evidence
References
- [1] Carlos Chocarro-Wrona et al.. Mater Today Bio. 2025. A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration. doi:10.1016/j.mtbio.2025.101592 PubMed
- [2] Jiarong Cui et al.. ACS Nano. 2025. Engineered Microalgal Extracellular Vesicles for Enhancing Mitochondrial Homeostasis in Radiodermatitis Prevention. doi:10.1021/acsnano.5c07135 PubMed
- [3] Zhengxin Suo et al.. Drug Deliv Transl Res. 2025. Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia. doi:10.1007/s13346-025-01816-w PubMed
- [4] Yudie Lv et al.. Int J Biol Macromol. 2025. Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration. doi:10.1016/j.ijbiomac.2025.146316 PubMed
- [5] Leo L Wang et al.. ACS Biomater Sci Eng. 2025. Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia. doi:10.1021/acsbiomaterials.5c00292 PubMed
- [6] Tao Ye et al.. Regen Biomater. 2025. Engineered collagen XVII-loaded dissolving microneedle patch for promoting hair regrowth in androgenic alopecia. doi:10.1093/rb/rbaf104 PubMed
- [7] Qin Yang et al.. Regen Biomater. 2024. Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment. doi:10.1093/rb/rbae086 PubMed
- [8] Yutong Xie et al.. J Dermatolog Treat. 2024. Cosmetic filler-induced hair loss: case series and literature review. doi:10.1080/09546634.2024.2443111 PubMed
- [9] Philip R Cohen et al.. Skinmed. 2019. Platelet-Rich Plasma and Genital Rejuvenation. PubMed
- [10] Douglas MacKay et al.. Altern Med Rev. 2003. Nutritional support for wound healing. PubMed
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