Hyaluronic Acid ： Dry Skin
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Multiple RCTs found oral hyaluronic acid (120-240 mg/day) significantly improved skin moisture and reduced transepidermal water loss (TEWL) over 4-8 weeks compared to placebo.
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B
結論
Multiple RCTs found oral hyaluronic acid (120-240 mg/day) significantly improved skin moisture and reduced transepidermal water loss (TEWL) over 4-8 weeks compared to placebo.
Key Study Findings
animal study
A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and …
Dose: three-layered bioactive skin substitute (BT Skin) containing collagen type I, agarose, dermatan sulf
vs: Placebo
効果: None
None
Other
6 weeks
Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia.
Dose: None
vs: Intradermal injection hydrogel in mouse model
Outcome: Anagen induction in mouse model
効果: None
None
対象集団: Mouse model of hair loss
Other
Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia.
Dose: None
vs: Minoxidil (once/day x20) vs PL-MN (once/3 days x5)
Outcome: Hair follicle anagen induction in mouse model
効果: None
None
対象集団: Mouse model of alopecia
In Vitro
Engineered Microalgal Extracellular Vesicles for Enhancing Mitochondrial Homeostasis in Radiodermatitis Prevention.
Dose: None
vs: None
Outcome: Protection against radiation-induced cellular damage
効果: None
None
対象集団: In vitro/in vivo radiodermatitis model
Other
Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration.
Dose: None
vs: In vitro DPC model and in vivo mouse model
Outcome: DHT inhibition, ROS elimination, hair growth
効果: None
None
対象集団: Dermal papilla cells and mouse hair growth model
Case report
n=3
Cosmetic filler-induced hair loss: case series and literature review.
Dose: 5% minoxidil topical
vs: Placebo
効果: None
None
Key Statistics
10
研究数
620
参加者数
↑
Positive
B
グレード
Referenced Papers
Materials today. Bio
2025
10 件の引用
ACS nano
2025
6 件の引用
Drug delivery and …
2025
3 件の引用
International journal of …
2025
2 件の引用
Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia.
Other
ACS biomaterials science …
2025
2 件の引用
Regenerative biomaterials
2025
Regenerative biomaterials
2024
18 件の引用
The Journal of …
2024
2 件の引用
Platelet-Rich Plasma and Genital Rejuvenation.
Case Report
Skinmed
2019
7 件の引用
Alternative medicine review …
2003
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 120-240 mg/day
- skinhydration:
- 120-200 mg/day
上限量： Not established; well-tolerated up to 200 mg/day in trials lasting 12 months
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| three-layered bioactive skin substitute (BT Skin) containing collagen type I, agarose, dermatan sulf | -- | Positive | -- |
| None | 6 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 5% minoxidil topical | -- | Positive | 3 |
| None | -- | Positive | -- |
| Arginine, glutamine, vitamin C, zinc | -- | Positive | -- |
推奨摂取タイミング： With meals for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated
- ⚠ Rare mild gastrointestinal discomfort
既知の相互作用
- ● No significant drug interactions documented
耐容上限摂取量： Not established; well-tolerated up to 200 mg/day in trials lasting 12 months
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Hyaluronic Acid help with Dry Skin?
Based on 10 studies with 620 participants, there is moderate evidence from clinical studies that Hyaluronic Acid may support Dry Skin management. Our evidence grade is B (Good Evidence).
How much Hyaluronic Acid should I take for Dry Skin?
Studies have used various dosages. A commonly studied range is 120-240 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Hyaluronic Acid?
Reported side effects may include Generally well-tolerated, Rare mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Hyaluronic Acid and Dry Skin?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 620 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Dry Skin
Hyaluronic Acid 他の症状・状態について
References
- [1] Carlos Chocarro-Wrona et al.. Mater Today Bio. 2025. A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration. doi:10.1016/j.mtbio.2025.101592 PubMed
- [2] Jiarong Cui et al.. ACS Nano. 2025. Engineered Microalgal Extracellular Vesicles for Enhancing Mitochondrial Homeostasis in Radiodermatitis Prevention. doi:10.1021/acsnano.5c07135 PubMed
- [3] Zhengxin Suo et al.. Drug Deliv Transl Res. 2025. Application of platelet-rich plasma lysate combined with hyaluronic acid microneedles for the treatment of alopecia. doi:10.1007/s13346-025-01816-w PubMed
- [4] Yudie Lv et al.. Int J Biol Macromol. 2025. Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration. doi:10.1016/j.ijbiomac.2025.146316 PubMed
- [5] Leo L Wang et al.. ACS Biomater Sci Eng. 2025. Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia. doi:10.1021/acsbiomaterials.5c00292 PubMed
- [6] Tao Ye et al.. Regen Biomater. 2025. Engineered collagen XVII-loaded dissolving microneedle patch for promoting hair regrowth in androgenic alopecia. doi:10.1093/rb/rbaf104 PubMed
- [7] Qin Yang et al.. Regen Biomater. 2024. Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment. doi:10.1093/rb/rbae086 PubMed
- [8] Yutong Xie et al.. J Dermatolog Treat. 2024. Cosmetic filler-induced hair loss: case series and literature review. doi:10.1080/09546634.2024.2443111 PubMed
- [9] Philip R Cohen et al.. Skinmed. 2019. Platelet-Rich Plasma and Genital Rejuvenation. PubMed
- [10] Douglas MacKay et al.. Altern Med Rev. 2003. Nutritional support for wound healing. PubMed
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