What is the recommended dosage for Vitamin A (Retinol)?

General: 700-900 mcg RAE/day (RDA); Skin Health: 700-900 mcg RAE/day (do not exceed UL)

What are the side effects of Vitamin A (Retinol)?

Potential side effects include: Headache and nausea at high doses, Skin dryness and peeling (hypervitaminosis A), Liver toxicity with chronic excess, Birth defects (teratogenic — pregnancy contraindication).

What is vitamin A (retinol) and how may it support skin health?

Vitamin A and its derivatives (retinoids) are fundamental to skin cell turnover, collagen production, and sebum regulation. While topical retinoids are well-established in dermatology, oral vitamin A at physiological doses supports normal skin cell differentiation. Oral isotretinoin (a prescription retinoid) is the most effective acne treatment available.

What dosage of vitamin A has been studied for skin health?

The RDA for vitamin A is 700–900 mcg RAE (2,300–3,000 IU) daily. Prescription-level doses (isotretinoin) for acne are 0.5–1 mg/kg/day and require medical supervision. Over-the-counter vitamin A supplements typically contain 750–1,500 mcg. Beta-carotene, a precursor, is safer at high doses as conversion is regulated by the body.

What are the potential side effects of vitamin A supplements?

Excessive preformed vitamin A (retinol) causes hypervitaminosis A, presenting as dry skin, peeling, headache, nausea, and in severe cases, liver damage. It is teratogenic and must be avoided during pregnancy. The tolerable upper intake level is 3,000 mcg (10,000 IU) for adults. Beta-carotene is much safer as a vitamin A source.

Vitamin A (Retinol)
Vitamin A (Retinol)

vitamin

Também conhecido como: Retinol, Retinyl Palmitate, Retinyl Acetate, Beta-Carotene (provitamin A), Preformed Vitamin A

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About

Vitamin A binds retinoic acid receptors (RARs) in skin cells to regulate keratinocyte differentiation, stimulate epidermal turnover, upregulate collagen gene expression, and inhibit matrix metalloproteinases (MMPs) that degrade collagen and elastin. While topical retinoids are the gold standard for photoaging and acne, oral vitamin A at RDA levels supports these processes from within.

How It Works

Binds retinoic acid receptors (RARs) in skin cells to regulate keratinocyte differentiation, stimulate epidermal turnover, upregulate collagen gene expression, and inhibit matrix metalloproteinases (MMPs) that degrade collagen and elastin.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Acne	C	6	400	Ver →
Aging Skin & Wrinkles	C	5	300	Ver →
Keratosis Pilaris	D	2	100	Ver →

Side Effects

Headache and nausea at high doses
Skin dryness and peeling (hypervitaminosis A)
Liver toxicity with chronic excess
Birth defects (teratogenic — pregnancy contraindication)

Drug & Supplement Interactions

Retinoid medications (additive toxicity risk — do not combine)
Tetracycline antibiotics (increased intracranial pressure risk)
Anticoagulants (high-dose vitamin A may increase bleeding risk)
Hepatotoxic drugs (additive liver stress)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Vitamin C Vitamin E Vitamin D Biotin Niacinamide

Dados Rápidos

Dosagem: General: 700-900 mcg RAE/day (RDA); Skin_Health: 700-900 mcg RAE/day (do not exceed UL)
Formas: softgel capsule liquid tablet
Fontes Naturais: Liver, Sweet potato, Carrots, Spinach, Eggs, Dairy
Limite Superior: 3,000 mcg RAE/day (10,000 IU preformed vitamin A) — teratogenic at high doses
Melhor Horário: With meals containing fat

Resumo das Evidências

Acne C

Aging Skin & Wrinkles C

Keratosis Pilaris D

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.