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Nicotinamide ： UV Protection (Internal Photoprotection)

A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。

At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).

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            A

        

        

            
結論

            
            
At chemoprevention doses (1,000 mg/day), oral nicotinamide replenishes UV-depleted NAD+ stores, enhancing cellular energy for DNA repair and supporting immune surveillance of UV-damaged cells (ONTRAC Phase 3 trial).

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                The adverse effects of oral niacin/nicotinamide - an overview of reviews.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Overview of reviews on niacin/nicotinamide adverse effects

            
        

        
        

            

                
                    Meta-Analysis
                
                
                
                
            

            
                The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
            
            

                
                Dose: Nicotinamide (vitamin B3)
                
                
                vs: Placebo
                
                
                Outcome: AK and NMSC incidence reduction
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: High-risk NMSC patients (RCTs)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, …
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                効果: None
                
                
                None
                
            

            
        

        
        

            

                
                    Other
                
                
                
                
            

            
                Nicotinamide: An Update and Review of Safety & Differences from Niacin.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Final report of the safety assessment of niacinamide and niacin.
            
            

                
                Dose: Niacinamide up to 5%; Niacin up to 0.1%
                
                
                vs: None
                
                
                Outcome: Safety assessment for cosmetic use
                
                
                効果: Safe as used in cosmetics
                
                
                None
                
            

            
            
対象集団: General population (cosmetic users)

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
5

        
研究数

    

    

        
686

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        A

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            The adverse effects of oral niacin/nicotinamide - an overview of reviews.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Eye (London, England)
                        2025
                        
                        1 件の引用
                        
                    

                

                
                

                    

                        
                            The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2023
                        
                        16 件の引用
                        
                    

                

                
                

                    

                        
                            Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Journal of the …
                        2021
                        
                        46 件の引用
                        
                    

                

                
                

                    

                        
                            Nicotinamide: An Update and Review of Safety & Differences from Niacin.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Skin therapy letter
                        2020
                        
                        13 件の引用
                        
                    

                

                
                

                    

                        
                            Final report of the safety assessment of niacinamide and niacin.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2005
                        
                        22 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
generalskinbarrier:

                        
500-1,500 mg/day

                    

                    
                    

                        
skincancerchemoprevention:

                        
500 mg twice daily (1,000 mg/day total)

                    

                    
                

                
                

                    上限量： Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                Nicotinamide (vitamin B3)
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                Niacinamide up to 5%; Niacin up to 0.1%
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals; split into 2 doses for chemoprevention
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated (no flushing)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare hepatotoxicity at very high doses
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticonvulsants (carbamazepine — may increase levels)
                        
    • 
                        
                        
  • 
                            ●
                            Isoniazid (competes for NAD+ pathways)
                        
    • 
                        
                        
  • 
                            ●
                            Hepatotoxic drugs (potential additive liver effect at high doses)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Generally well-tolerated up to 3,000 mg/day (no flushing unlike niacin)
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Nicotinamide help with UV Protection (Internal Photoprotection)?
            
        
        

            Based on 5 studies with 686 participants, there is strong evidence from multiple clinical trials that Nicotinamide may support UV Protection (Internal Photoprotection) management. Our evidence grade is A (Strong Evidence).
        

    

    
    

        
            How much Nicotinamide should I take for UV Protection (Internal Photoprotection)?
            
        
        

            Studies have used various dosages. A commonly studied range is 500-1,500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Nicotinamide?
            
        
        

            Reported side effects may include Generally well-tolerated (no flushing), Mild gastrointestinal discomfort at high doses, Rare hepatotoxicity at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Nicotinamide and UV Protection (Internal Photoprotection)?
            
        
        

            We rate the evidence as Grade A (Strong Evidence). This rating is based on 5 peer-reviewed studies with 686 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Su Ling Young et al..
      Eye (Lond).
      2025.
      The adverse effects of oral niacin/nicotinamide - an overview of reviews.
      doi:10.1038/s41433-025-04027-2
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Giulio Tosti et al..
      Nutrients.
      2023.
      The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16010100
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Katherine G Thompson et al..
      J Am Acad Dermatol.
      2021.
      Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium.
      doi:10.1016/j.jaad.2020.04.123
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Reed Huber et al..
      Skin Therapy Lett.
      2020.
      Nicotinamide: An Update and Review of Safety & Differences from Niacin.
      
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Cosmetic Ingredient Review Expert Panel.
      Int J Toxicol.
      2005.
      Final report of the safety assessment of niacinamide and niacin.
      doi:10.1080/10915810500434183
      PubMed
    
    6. 
    
  















    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。