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SkinCited

MSM for Aging Skin & Wrinkles

C Some Evidence Limited evidence from small studies, but some positive signals exist.

A clinical trial found MSM (3,000 mg/day for 16 weeks) improved skin texture and firmness. MSM provides sulfur for disulfide bonds in collagen, elastin, and keratin.

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The Bottom Line

            
            
A clinical trial found MSM (3,000 mg/day for 16 weeks) improved skin texture and firmness. MSM provides sulfur for disulfide bonds in collagen, elastin, and keratin.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=83
                
                
                16 weeks
                
                
                Double-blind
                
            

            
                Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing.
            
            

                
                Dose: 1 g/d or 3 g/d
                
                
                vs: Placebo (Part I); 1g vs 3g dose (Part II)
                
                
                Outcome: Facial wrinkles, skin firmness, elasticity, hydration
                
                
                Effect: None
                
                
                p<0.05
                
            

            
            
Population: Healthy adults with signs of skin aging

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
Studies

    

    

        
180

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        International journal for …
                        2022
                        
                        10 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
1,000-3,000 mg/day

                    

                    
                    

                        
skinhealth:

                        
1,000-3,000 mg/day

                    

                    
                

                
                

                    Upper limit: Generally well-tolerated up to 6,000 mg/day
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                1 g/d or 3 g/d
                                16 weeks
                                
                                    
                                    Positive
                                    
                                
                                83
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With meals; can be split into 2-3 doses
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia (rare)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (theoretical interaction)
                        
    • 
                        
                        
  • 
                            ●
                            Generally considered safe with minimal drug interactions
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Generally well-tolerated up to 6,000 mg/day
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does MSM help with Aging Skin & Wrinkles?
            
        
        

            Based on 3 studies with 180 participants, there is limited but promising evidence that MSM may support Aging Skin & Wrinkles management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much MSM should I take for Aging Skin & Wrinkles?
            
        
        

            Studies have used various dosages. A commonly studied range is 1,000-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of MSM?
            
        
        

            Reported side effects may include Mild gastrointestinal discomfort, Headache (rare), Insomnia (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for MSM and Aging Skin & Wrinkles?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 180 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Neelam Muizzuddin et al..
      Int J Vitam Nutr Res.
      2022.
      Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing.
      doi:10.1024/0300-9831/a000643
      PubMed
    
    2. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.