Vitamin D لـ Vitiligo
D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).Research suggests vitamin D deficiency is common in vitiligo patients. Supplementation may support melanocyte function, but clinical evidence for repigmentation is limited.
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D
الخلاصة
Research suggests vitamin D deficiency is common in vitiligo patients. Supplementation may support melanocyte function, but clinical evidence for repigmentation is limited.
Key Study Findings
retrospective observational with Mendelian randomization
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Dose: None
مقابل: Placebo
التأثير: OR 1.86 (95% CI 1.19-2.92)
0.007
Observational Study
n=573
Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.
Dose: None
مقابل: None
Outcome: Vitiligo prevalence and clinical characteristics
التأثير: None
None
المجتمع المدروس: Saudi patients with vitiligo (573)
Meta-Analysis
n=680823
Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis.
Dose: None
مقابل: Placebo
التأثير: Vitamin D deficiency OR 10.13 (95% CI 4.24-24.20)
None
Case-control
n=90
Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata …
Dose: None
مقابل: Placebo
التأثير: None
p=0.001 (BDNF and vitamin D vs
Observational Study
Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study.
Dose: 36%
مقابل: None
Outcome: hair regrowth
التأثير: None
p < 0.05
المجتمع المدروس: Aa referred to our hospitals between 2018 and 2021
Other
n=38
36 weeks
Paediatric lichen sclerosus et atrophicus: A retrospective analysis of 38 paediatric patients.
Dose: 92.1%
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: lsa by a paediatric dermatologist
Key Statistics
4
الدراسات
300
المشاركون
↑
Positive
D
التقييم
Referenced Papers
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.
Other
Skin research and …
2024
Clinical, cosmetic and …
2024
Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis.
Meta-Analysis
American journal of …
2023
41 اقتباسات
Health science reports
2023
3 اقتباسات
Journal of cosmetic …
2023
3 اقتباسات
Paediatric lichen sclerosus et atrophicus: A retrospective analysis of 38 paediatric patients.
Other
International journal of …
2021
14 اقتباسات
Journal of the …
2020
57 اقتباسات
American journal of …
2018
138 اقتباسات
Postepy dermatologii i …
2016
59 اقتباسات
The British journal …
2014
74 اقتباسات
Off-label uses of topical vitamin D in dermatology: a systematic review.
Systematic Review
Journal of cutaneous …
2014
35 اقتباسات
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 600-800 IU/day (RDA)
- skinhealth:
- 1,000-4,000 IU/day (targeting 30-50 ng/mL serum 25(OH)D)
الحد الأعلى: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Neutral | 573 |
| None | -- | Positive | 680823 |
| None | -- | Negative | 90 |
| 36% | -- | Mixed | -- |
| 92.1% | 36 weeks | Positive | 38 |
| None | -- | Positive | 8314220 |
| None | -- | Negative | -- |
أفضل وقت للتناول: With meals containing fat for better absorption
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Generally well-tolerated at recommended doses
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones (rare, at excessive doses)
التفاعلات المعروفة
- ● Thiazide diuretics (may increase calcium levels)
- ● Corticosteroids (may reduce vitamin D absorption)
- ● Orlistat and cholestyramine (reduce absorption of fat-soluble vitamins)
- ● Calcipotriene (additive vitamin D effect)
الحد الأقصى المسموح به: 4,000 IU/day (IOM); many experts consider up to 10,000 IU/day safe
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Vitamin D help with Vitiligo?
Based on 4 studies with 300 participants, there is preliminary evidence that needs more research that Vitamin D may support Vitiligo management. Our evidence grade is D (Very Early Research).
How much Vitamin D should I take for Vitiligo?
Studies have used various dosages. A commonly studied range is 600-800 IU/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Generally well-tolerated at recommended doses, Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones (rare, at excessive doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Vitiligo?
We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Vitamin D لحالات أخرى
References
- [1] Yuting Cao et al.. Skin Res Technol. 2024. Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study. doi:10.1111/srt.13911 PubMed
- [2] Mohammed Ibrahim AlJasser. Clin Cosmet Investig Dermatol. 2024. Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients. doi:10.2147/CCID.S499794 PubMed
- [3] Sophia Ly et al.. Am J Clin Dermatol. 2023. Comorbid Conditions Associated with Alopecia Areata: A Systematic Review and Meta-analysis. doi:10.1007/s40257-023-00805-4 PubMed
- [4] Elham Hamidpour et al.. Health Sci Rep. 2023. Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study. doi:10.1002/hsr2.1444 PubMed
- [5] N M Dawoud et al.. J Cosmet Dermatol. 2023. Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … doi:10.1111/jocd.15725 PubMed
- [6] Basak Yalici-Armagan et al.. Int J Clin Pract. 2021. Paediatric lichen sclerosus et atrophicus: A retrospective analysis of 38 paediatric patients. doi:10.1111/ijcp.14661 PubMed
- [7] R Z Conic et al.. J Eur Acad Dermatol Venereol. 2020. Comorbidities in pediatric alopecia areata. doi:10.1111/jdv.16727 PubMed
- [8] Elio Kechichian et al.. Am J Clin Dermatol. 2018. Vitamin D and the Skin: An Update for Dermatologists. doi:10.1007/s40257-017-0323-8 PubMed
- [9] Ebru Karagün et al.. Postepy Dermatol Alergol. 2016. The role of serum vitamin D levels in vitiligo. doi:10.5114/pdia.2016.59507 PubMed
- [10] A Aksu Cerman et al.. Br J Dermatol. 2014. Vitamin D deficiency in alopecia areata. doi:10.1111/bjd.12980 PubMed
- [11] Heidi Wat et al.. J Cutan Med Surg. 2014. Off-label uses of topical vitamin D in dermatology: a systematic review. doi:10.2310/7750.2013.13109 PubMed
- [12] Nanette B Silverberg. Pediatr Clin North Am. 2014. Pediatric vitiligo. doi:10.1016/j.pcl.2013.11.008 PubMed
- [13] Michael P Pender. Autoimmune Dis. 2012. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis. doi:10.1155/2012/189096 PubMed
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