What is the recommended dosage for Pantothenic Acid?

General: 5 mg/day (AI); Acne Skin Health: 500-2,000 mg/day (high-dose protocol)

What are the side effects of Pantothenic Acid?

Potential side effects include: Diarrhea at very high doses, Mild gastrointestinal discomfort.

What is pantothenic acid and how may it support skin health?

Pantothenic acid (vitamin B5) is involved in coenzyme A synthesis, which is critical for fatty acid metabolism and skin barrier lipid production. It is widely used in topical skincare as dexpanthenol. Some clinical evidence suggests high-dose oral pantothenic acid may reduce acne lesions, possibly through improved lipid metabolism.

What dosage of pantothenic acid has been studied for acne?

An RCT found that a pantothenic acid-based supplement at an equivalent of approximately 2,200 mg B5 per day significantly reduced acne lesions after 12 weeks. Earlier observational studies used much higher doses (up to 10 grams daily), which are not recommended. The Adequate Intake is only 5 mg for adults.

What are the potential side effects of pantothenic acid supplements?

Pantothenic acid is generally well tolerated at moderate supplemental doses. Very high doses (above 10 grams daily) may cause diarrhea and gastrointestinal distress. No tolerable upper intake level has been established. At studied acne doses (2–5 grams), mild digestive discomfort has been reported. Topical dexpanthenol is very well tolerated.

Pantothenic Acid
Pantothenic Acid

other

Também conhecido como: Vitamin B5, Calcium D-Pantothenate, Dexpanthenol (topical), D-Pantothenic Acid

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Pantothenic acid is a precursor to coenzyme A (CoA), essential for fatty acid synthesis. A randomized double-blind trial found high-dose pantothenic acid (2,200 mg/day for 12 weeks) significantly reduced total facial acne lesions by 68.2%. The high doses required are considerably above the AI (5 mg/day).

How It Works

Precursor to coenzyme A (CoA), essential for fatty acid synthesis and metabolism; supports skin barrier lipid production; high-dose supplementation may redirect CoA toward fatty acid oxidation in sebaceous glands, potentially reducing sebum production and acne.

Evidence For Conditions

Condição	Nota	Estudos	Participantes
Acne	C	3	200	Ver →

Side Effects

Diarrhea at very high doses
Mild gastrointestinal discomfort

Drug & Supplement Interactions

No significant drug interactions documented at typical doses
May enhance acetylcholine production (theoretical interaction with cholinergic drugs)

Informe sempre o seu profissional de saúde sobre todos os suplementos que você toma.Sempre informe seu profissional de saúde sobre todos os suplementos que você toma.

Related Ingredients

Vitamin K N-Acetyl Cysteine

Dados Rápidos

Dosagem: General: 5 mg/day (AI); Acne_Skin_Health: 500-2,000 mg/day (high-dose protocol)
Formas: capsule tablet powder topical (dexpanthenol)
Fontes Naturais: Liver, Chicken, Sunflower seeds, Mushrooms, Avocado, Yogurt, Whole grains
Limite Superior: Not established; high doses (10,000+ mg/day) may cause GI distress
Melhor Horário: With meals; split doses recommended for high amounts

Resumo das Evidências

Acne C

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.